Can First-Generation Retinoids Be Used for Daily Skincare? - Dermatology

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Can first-generation retinoids be used for daily skincare?


Currently, the only topical first-generation retinoid (tretinoin 0.1%) available seems to be from the Chinese company, which is classified as a "prescription medication" (this concentration appears to be a prescription drug abroad).
Recently, I researched the topic of photoaging and learned that tretinoin can help reduce the symptoms of photoaging, thicken the dermis, and promote collagen regeneration, among other benefits.
This has led me to consider starting its use, but I have some questions for the physician:
1.
Is tretinoin, as a prescription medication, generally more effective and safer compared to over-the-counter "anti-aging cosmetics"?
2.
I am currently 24 years old and have been using tretinoin for nearly three months, applying a pea-sized amount mixed with about ten times the amount of a moisturizing cream over my entire face.
I have been diligent with sun protection, and while I occasionally experience redness and peeling, it resolves after stopping the medication for two to three days.
Can I continue this method as a daily anti-aging regimen?
3.
Most literature indicates that tretinoin can alleviate various signs of skin aging.
Is there clinical evidence or examples supporting the idea of "preventive" measures before aging occurs? Or is it sufficient to focus on basic sun protection in youth and only use tretinoin to address photoaging symptoms once they appear?

Lan Mi, 20~29 year old female. Ask Date: 2018/01/22

Dr. Li Yufen reply Dermatology


Hello: Regarding the types of topical retinoic acid, their mechanisms of action, effects, and side effects, you can refer to Dr.
Wang Hsiu-Han's articles at the following links: http://www.skin168.net/2013/09/topical-retinoic-acid-generations.html, http://www.skin168.net/2013/09/retinoic-acid-mechanism.html, http://www.skin168.net/2013/09/topical-retinoic-acid-cautions.html.
Due to occasional redness and peeling as a side effect, it is not recommended to use first-generation retinoic acid as a daily skincare product for an extended period.
You might consider trying a milder third-generation retinoic acid to see if your skin can adapt, and ensure proper sun protection to prevent photoaging.
Thank you!

Reply Date: 2018/01/22

More Info


Using first-generation retinoids, such as tretinoin (0.1%), for daily skincare has become a topic of interest, especially among those looking to combat signs of aging and improve skin texture. Tretinoin is known for its ability to enhance collagen production, promote skin cell turnover, and reduce the appearance of fine lines and wrinkles. However, there are several important considerations to keep in mind regarding its use, particularly for younger individuals like yourself.

1. Effectiveness and Safety Compared to Over-the-Counter Products: Tretinoin is indeed a prescription-strength medication that is generally more potent than many over-the-counter anti-aging products. While OTC products may contain ingredients like retinol, which is a less potent form of vitamin A, tretinoin has been extensively studied and is often considered the gold standard for treating photoaging and acne. However, with increased potency comes a higher risk of side effects, such as irritation, redness, and peeling. Therefore, while tretinoin may be more effective, it is essential to use it cautiously and under the guidance of a healthcare professional.

2. Daily Use and Skin Tolerance: You mentioned using a pea-sized amount of tretinoin mixed with a moisturizer and applying it to your entire face. This method can help mitigate some of the irritation associated with tretinoin, especially for those with sensitive skin. However, it is crucial to monitor your skin's response. Occasional redness and peeling are common, but if these symptoms persist or worsen, it may be wise to reduce the frequency of application or switch to a lower concentration or a gentler formulation, such as a third-generation retinoid. Long-term daily use of tretinoin can be beneficial, but it should be approached with caution, especially if you experience significant irritation.

3. Preventive Use of Tretinoin: The concept of using tretinoin as a preventive measure against aging is supported by some clinical studies. Research indicates that starting retinoid therapy in your 20s can help maintain skin health and prevent the onset of visible aging signs. However, the most critical preventive measure remains sun protection. Daily use of broad-spectrum sunscreen is essential, as UV exposure is a significant contributor to skin aging. While incorporating tretinoin can be beneficial, it should complement a comprehensive skincare routine that prioritizes sun protection and hydration.

In summary, while first-generation retinoids like tretinoin can be effective for daily skincare, especially for anti-aging purposes, it is essential to use them judiciously. Start with a lower frequency of application, monitor your skin's tolerance, and always prioritize sun protection. Consulting with a dermatologist can provide personalized guidance tailored to your skin type and concerns, ensuring that you achieve the best results while minimizing potential side effects.

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