Genital Herpes: Common Questions and Expert Answers - Urology

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133315 Questions about genital herpes?


Dear Dr.
Du,
Thank you for your explanation regarding #133315.
I would like to ask you a few more questions:
1) You mentioned that "the antibody tests available in the market...
therefore, even if the result is positive, it does not indicate the presence of the herpes virus on the skin, nor can it distinguish between skin, oral, or genital infections." Dr.
Du, there are specific tests for HSV-1 and HSV-2 available at laboratories.
If my blood test shows a high level of HSV-1 above the threshold of 1.1, while HSV-2 levels are between 1.2 and 1.34, does this mean I can differentiate between oral herpes (HSV-1) and genital herpes (HSV-2)?
2) You stated, "So you must have been infected, but because you are asymptomatic, it is possible that the viral load is low or that the virus is not present on the skin, making transmission less likely." Dr.
Du, does "having been infected" refer specifically to genital herpes, or does it imply a general herpes simplex virus infection without distinguishing between type 1 or type 2?
3) I have not had an outbreak of genital herpes in the past 20 years.
Is there a high chance of suddenly experiencing an outbreak in the future?
4) Throughout our marriage, my partner and I have had unprotected sexual intercourse (my wife tested negative for HSV-2 IgG).
Can we continue this practice in the future?
I apologize for the long list of questions, and I appreciate your time in clarifying these matters.
Thank you.

Du Fen Si, 50~59 year old female. Ask Date: 2018/02/26

Dr. Du Shixi reply Urology


Hello: HSV is not limited to a specific area; for example, HSV-1 is not exclusively an oral infection.
(So if someone tests positive for HSV-1, it only indicates an infection, but it cannot be definitively stated that it is an oral infection.) 2) A high HSV-1 index may indicate a past HSV-1 infection.
3) The likelihood is low, but it is possible if the immune system is significantly weakened.
4) Yes, it is possible.
Unless symptoms appear, it indicates that the virus is active.
Wishing you good health.

Reply Date: 2018/02/26

More Info


Understanding genital herpes, particularly the distinctions between HSV-1 and HSV-2, is crucial for managing and preventing the spread of this common viral infection. Let's address your questions one by one.

1. Specific Antibody Testing for HSV-1 and HSV-2: You mentioned that you underwent testing that differentiated between HSV-1 and HSV-2. This is indeed possible with specific serological tests that measure antibodies against these viruses. HSV-1 is typically associated with oral herpes, while HSV-2 is more commonly linked to genital herpes. However, both types can cause infections in either area. A high HSV-1 antibody level indicates a past infection, which is common as many people are exposed to HSV-1 during childhood. The HSV-2 levels you mentioned being between 1.2 and 1.34 suggest a low-level exposure or infection. It’s important to note that a positive HSV-2 result does not necessarily mean you have an active genital herpes infection, especially if you have not experienced any symptoms.

2. Understanding Past Infections: When I mentioned that you have likely been infected, it refers to the presence of antibodies in your blood. This could be from either HSV-1 or HSV-2, but without symptoms, it’s challenging to determine the specific type of herpes virus responsible for the antibodies. The presence of antibodies indicates that your immune system has encountered the virus at some point, but it does not confirm an active infection or the location of the infection (oral or genital).

3. Risk of Future Outbreaks: The fact that you have not had an outbreak in 20 years is a positive sign. While herpes is a lifelong infection, many individuals experience long periods without symptoms. The likelihood of an outbreak can increase due to various factors such as stress, illness, or a weakened immune system. However, many people live with the virus without ever experiencing noticeable symptoms again. It’s essential to maintain a healthy lifestyle and manage stress to minimize the risk of outbreaks.

4. Contraceptive Practices: Given that your partner has tested negative for HSV-2, the risk of transmission during unprotected intercourse is low, especially if you are asymptomatic. However, it’s important to communicate openly with your partner about your HSV-1 and HSV-2 status. While the risk of transmission is lower when there are no active lesions, it is not zero. If you do experience an outbreak, it is advisable to avoid sexual contact until the sores have healed. Additionally, using condoms can further reduce the risk of transmission, even when asymptomatic.

In summary, understanding your HSV status and the implications of your test results is vital for managing your health and that of your partner. Regular communication with your healthcare provider about any changes in your health or symptoms is essential. If you have further questions or concerns, consider consulting a specialist in infectious diseases or a dermatologist who can provide more personalized guidance based on your medical history.

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