Managing Medication Side Effects in Urology: A Patient's Guide - Urology

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Medication issues


Hello, Doctor.
I recently sought medical attention due to itching in my urethra.
After a urinalysis, I was diagnosed with prostatitis, and the physician prescribed a two-week course of medication, including Pain Relief, Oxybutynin Extended-Release Tablets, and Uroflow.
After taking the medication for one day, I experienced retrograde ejaculation the following day.
Upon checking the medication packaging, I found that this is a noted side effect of Oxybutynin.
Should I stop the medication immediately and return for a follow-up, or should I continue taking it until the course is completed? Will the ejaculation issue resolve on its own? Thank you.

Mr. Chen, 30~39 year old female. Ask Date: 2018/03/09

Dr. Du Shixi reply Urology


Hello: Many medications for the prostate can cause retrograde ejaculation, but the extent varies.
If you are very concerned about the sensation of retrograde ejaculation, you can stop the medication, and it will often return to normal.
If you still experience urethral itching, you should seek medical attention to change the medication.
Wishing you good health.

Reply Date: 2018/03/09

More Info


Managing medication side effects, especially in urology, can be a complex issue for patients. In your case, you have been prescribed medications for prostatitis, including pain relief and Urief (also known as fesoterodine), which is commonly used to treat overactive bladder symptoms. One of the known side effects of Urief is retrograde ejaculation, which occurs when semen enters the bladder instead of exiting through the penis during ejaculation. This can understandably cause concern for many patients.

First and foremost, it is essential to understand that retrograde ejaculation is generally not harmful and does not indicate a serious underlying health issue. It is primarily a side effect of certain medications, including Urief. The good news is that this side effect is often reversible. Once you stop taking the medication, normal ejaculation typically resumes, although the timeline for recovery can vary from person to person.

Regarding your question about whether to stop the medication or continue until the end of the treatment course, it is advisable to consult your prescribing physician. They can provide personalized guidance based on your overall health, the severity of your symptoms, and the importance of completing the prescribed treatment for your prostatitis. If the retrograde ejaculation is causing significant distress or impacting your quality of life, your doctor may consider adjusting your medication or switching to an alternative treatment that does not carry this side effect.

In addition to discussing the medication with your doctor, it is also crucial to monitor any other side effects you may experience while on these medications. Common side effects of Urief can include dry mouth, constipation, and dizziness, which can affect your daily activities. If you experience any severe or concerning symptoms, such as persistent pain, changes in urination patterns, or any new symptoms, it is essential to seek medical attention promptly.

Furthermore, managing prostatitis often involves a multifaceted approach. Alongside medication, lifestyle changes such as staying hydrated, practicing pelvic floor exercises, and avoiding irritants (like caffeine and alcohol) can be beneficial. Regular follow-ups with your healthcare provider are also important to assess the effectiveness of the treatment and make any necessary adjustments.

In summary, while retrograde ejaculation can be an unsettling side effect of Urief, it is typically reversible upon discontinuation of the medication. It is crucial to maintain open communication with your healthcare provider regarding your symptoms and any side effects you experience. They can help you navigate your treatment plan effectively, ensuring that you receive the best care tailored to your needs. Always prioritize your health and well-being by seeking professional advice when in doubt.

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