Syphilis Treatment and Transmission Concerns - Urology

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Treatment and Transmission of Syphilis


Hello, Doctor:
1.
I was diagnosed with syphilis in mid-April 2018, after having tested negative in early June 2017.
The physician treating me said that a single injection of Benzathine Penicillin is sufficient for treatment within a year of infection.
However, I am concerned since it is now very close to a year.
Is one injection really enough? I have seen many people receiving three injections, and I am quite worried.
The doctor insists that one injection is sufficient.
2.
My partner was also infected by me and is undergoing treatment as well, receiving the same single injection (but from a different physician).
Should we refrain from sexual activity for three months? I am worried that if one of us recovers while the other does not, the recovered person might get reinfected.
3.
If I share a meal with family or friends, is there a significant risk of transmitting the infection to them (after starting treatment)? I am constantly worried about potentially harming them.
4.
My doctor has asked me to return for a follow-up in three months, while my partner's doctor has requested a follow-up in one month.
Can treatment progress be assessed in just one month?
5.
How long will it take for lymphadenopathy caused by syphilis to resolve after treatment? Will it continue to remain swollen? I have unilateral inguinal lymphadenopathy.
Thank you for your response, Doctor.

Chen, 20~29 year old female. Ask Date: 2018/04/26

Dr. Chen Jiansheng reply Urology


Primary, secondary, or early latent syphilis - long-acting benzathine penicillin is indicated, with a single injection completing the treatment; it is most suitable for patients who cannot receive daily injections and have poor compliance.
Method: Administer Benzathine penicillin, 2.4 million units intramuscularly in a single dose immediately after diagnosis (as recommended by the CDC).
If the partner is infected, it is advised to abstain for a while until the partner's tests confirm no syphilis infection.
Syphilis is transmitted through blood or sexual contact; it is not transmitted through normal daily activities.
The physician will ask the patient to return for a follow-up appointment in one month, although there may be specific considerations depending on the individual patient.
Lymphadenopathy may take several weeks to resolve, depending on the patient's constitution.

Reply Date: 2018/04/26

More Info


Syphilis, a sexually transmitted infection caused by the bacterium Treponema pallidum, can be effectively treated, but understanding the nuances of treatment and transmission is crucial for both the patient and their partners. Let's address your concerns one by one.

1. Treatment with Benzathine Penicillin: The standard treatment for early syphilis is indeed a single intramuscular injection of Benzathine Penicillin G. This is generally effective for primary and secondary syphilis. If your infection was diagnosed within a year, a single dose is typically sufficient. However, if there are any signs of late latent syphilis or if the infection has been present for more than a year, the treatment protocol usually involves three doses administered at weekly intervals. It’s understandable to feel anxious about the adequacy of treatment, especially when you hear about different protocols. If your doctor has assessed your condition and determined that a single injection is appropriate, it is likely based on clinical guidelines and your specific situation. However, if you have lingering concerns, it may be worthwhile to seek a second opinion or discuss further testing to confirm the infection has been cleared.

2. Sexual Activity During Treatment: It is crucial for both you and your partner to refrain from sexual activity until both of you have completed treatment and have been cleared by your respective healthcare providers. This is to prevent reinfection and ensure that the treatment is effective. The concern about one partner being cured while the other is not is valid, as this could lead to a cycle of reinfection. Open communication with your partner about treatment progress and following your healthcare provider's advice is essential.

3. Transmission Risks with Household Contacts: Syphilis is primarily transmitted through sexual contact, and the risk of transmission through casual contact, such as sharing utensils or dining together, is extremely low. As long as there are no open sores or lesions present, the risk of transmitting syphilis to family or friends through shared meals is negligible. However, it’s always wise to maintain good hygiene practices and avoid sharing personal items that may come into contact with bodily fluids.

4. Follow-Up Appointments: The timing of follow-up appointments can vary based on the physician's protocol and the patient's specific circumstances. Generally, follow-up visits are recommended at 3, 6, and 12 months after treatment to monitor for any signs of reinfection or treatment failure. Your partner’s doctor may have a different protocol based on their clinical judgment. It’s important for both of you to keep your follow-up appointments and discuss any concerns with your respective healthcare providers.

5. Lymphadenopathy Resolution: Lymph node swelling (lymphadenopathy) associated with syphilis can take time to resolve after treatment. Typically, you may start to notice a reduction in swelling within a few weeks to a few months after effective treatment. However, the exact timeline can vary from person to person. If the lymph nodes remain swollen for an extended period or if you experience any new symptoms, it’s important to follow up with your healthcare provider for further evaluation.

In summary, syphilis is treatable, and with proper medical guidance, both you and your partner can effectively manage the infection. Communication with your healthcare providers and each other is key to ensuring a successful treatment outcome. If you have any lingering doubts or symptoms, do not hesitate to reach out to your healthcare provider for further clarification and support.

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