Muscle Twitches and Weakness: A Neurological Perspective - Neurology

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Muscle twitching and weakness?


Hello, doctor.
Last Tuesday, I visited the neurology department with complaints of facial nerve dysfunction and decreased dexterity in my right hand.
During my follow-up appointment this Tuesday, my right hand is still not functioning well.
I am very afraid that I might have amyotrophic lateral sclerosis (ALS), which is making it difficult for me to concentrate on my studies and has even affected my sleep quality.
The doctor used a reflex hammer and said it’s not ALS, but informed me that muscle twitching can occur with the condition.
Starting Wednesday, I began to feel constant muscle twitching, which has continued to this day, affecting my entire body, including my left leg and lower back, but especially in my right hand, right shoulder, right foot, and right calf, where the twitching is most pronounced.

Since Thursday, I have noticed that my left hand is also becoming less dexterous, particularly in my middle, ring, and little fingers.
I feel some weakness in the thenar muscle as well.
Starting Friday, I have experienced soreness and weakness in my right calf, which has also been twitching.
As of today, my left foot and calf have started twitching too.
Currently, my main symptoms are:
- Right hand: Burning sensation in the fingers except for the thumb (dorsal side), with the little finger (palmar side) extending to the elbow occasionally feeling numb, tingling, and weak.
The thumb twitches and feels painful when exerted, with the thenar muscle extending to the elbow also feeling sore.
- Left hand: Weakness in the little finger, ring finger, and middle finger (palmar side) extending to the elbow.
- Right leg: Weakness and twitching in the calf, extending to just below the thigh, with weakness and soreness in the shoulder and twitching.
I have scoliosis, but the doctor said it’s not severe, with a slight leg length discrepancy.
I frequently use a computer and write, and occasionally use my hands as a pillow while sleeping.
Currently, I have no issues holding a pen or using chopsticks.

I kindly ask the doctor to explain what these symptoms might be.
I am truly frightened of ALS, which has caused me to feel chest tightness, shortness of breath, and constant anxiety.
I feel fatigued every day.
Thank you.

Hao, 10~19 year old female. Ask Date: 2018/05/05

Dr. Jiang Junyi reply Neurology


Hello: The symptoms you mentioned, combined with sensory abnormalities, may suggest peripheral nerve inflammation.
Amyotrophic lateral sclerosis (ALS) primarily affects motor neurons and typically does not present with sensory abnormalities.
Regarding fasciculations, they are associated with lower motor neuron (motor neurons located below the brainstem and spinal cord) pathology, which usually accompanies muscle atrophy.
This often starts in the palms or soles and then spreads upwards, affecting the thighs, arms, shoulders, neck, tongue, and respiratory muscles.
Most ALS patients will also experience upper motor neuron involvement, leading to symptoms such as limb stiffness, lack of coordination, muscle rigidity, and even severe cramps, along with exaggerated reflexes in the limbs.
If fasciculations occur without significant muscle atrophy, peripheral nerve inflammation should be considered, especially if there is instability caused by factors such as excessive coffee consumption and lack of sleep.
Peripheral nerve inflammation typically improves within two to three weeks, and lifestyle changes should be made, including daytime supplementation of B vitamins.
Since motor neuron diseases are progressive, if symptoms continue to worsen, further testing is necessary.
I recommend consulting a neurologist (a specialist in neuromuscular diseases) for discussion and treatment.
Wishing you good health and peace.
Dr.
Tao, Neurology Department, cares about you.

Reply Date: 2018/05/05

More Info


Understanding muscle twitches and weakness can be quite distressing, especially when you are concerned about serious conditions like Amyotrophic Lateral Sclerosis (ALS), commonly known as Lou Gehrig's disease. Your symptoms, including muscle twitching, weakness, and discomfort in various parts of your body, can understandably lead to anxiety and fear about your health.

First, it's important to clarify what muscle twitching (also known as fasciculations) and weakness mean in a neurological context. Muscle twitching can occur for a variety of reasons, including benign conditions such as stress, fatigue, or even caffeine intake. In contrast, muscle weakness can range from a slight decrease in strength to an inability to move a limb. In the context of ALS, muscle weakness typically progresses over time and is accompanied by muscle atrophy (wasting), spasticity, and other neurological signs.

From your description, it seems you are experiencing a range of symptoms affecting both sides of your body, particularly your right side. The fact that you have been evaluated by a neurologist and have undergone tests such as electromyography (EMG) and nerve conduction studies, which have ruled out significant neurological disorders, is reassuring. These tests are crucial in diagnosing conditions affecting the motor neurons, and a normal result significantly lowers the likelihood of ALS.

Your symptoms of muscle twitching and weakness could be attributed to several factors:
1. Anxiety and Stress: Anxiety can manifest physically in various ways, including muscle tension and twitching. The fear of having a serious illness can exacerbate these symptoms, creating a cycle of anxiety and physical discomfort. It's essential to address the psychological aspect of your symptoms, as managing anxiety can often lead to an improvement in physical symptoms.

2. Posture and Ergonomics: Given that you spend considerable time using a computer and writing, poor posture or repetitive strain could contribute to your symptoms. Conditions like thoracic outlet syndrome or carpal tunnel syndrome can cause symptoms similar to what you are experiencing, including weakness and discomfort in the arms and hands.

3. Neuromuscular Conditions: While ALS is a serious concern, other neuromuscular conditions can cause similar symptoms but are often less severe and more manageable. Conditions such as benign fasciculation syndrome or myofascial pain syndrome could be potential considerations.

4. Physical Deconditioning: If you have been less active due to your symptoms, muscle weakness can develop from disuse. Engaging in gentle exercises, as tolerated, can help improve strength and reduce discomfort.

5. Spinal Issues: You mentioned having scoliosis and a slight leg length discrepancy. These structural issues can sometimes lead to nerve compression or altered biomechanics, which could contribute to your symptoms.

Given your ongoing concerns, it would be beneficial to follow up with your healthcare provider. A multidisciplinary approach, including consultation with a physical therapist, may help address any musculoskeletal issues and improve your overall function. Additionally, if anxiety continues to be a significant factor, speaking with a mental health professional could provide strategies to manage your fears and improve your quality of life.

In summary, while your symptoms are understandably concerning, the absence of definitive neurological findings is a positive sign. Focus on managing anxiety, improving ergonomics, and maintaining physical activity as tolerated. If symptoms persist or worsen, further evaluation may be warranted to explore other potential causes. Remember, you are not alone in this journey, and seeking support from healthcare professionals can provide clarity and reassurance.

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