Viartril-S: Interactions with Viagra and Safety Concerns

Medication Consultation

I take Viartril-S daily.
Is this medication classified as a nitrate? Can I also take Viagra? Will there be any interactions or side effects between the two medications? Thank you!

Cai Ren, 60~69 year old female. Ask Date: 2018/05/06

Dr. Xiao Yongxun reply Family Medicine

Dear Sir/Madam,
1.
Sildenafil (Viagra®) is the Chinese term for 威而鋼 and belongs to the class of PDE-5 inhibitors.
PDE-5 is responsible for terminating the action of cGMP in the corpus cavernosum, preventing the smooth muscle in the arteries from relaxing and allowing for penile erection.
Sildenafil, as a PDE-5 inhibitor, prevents the action of PDE-5, leading to prolonged effects of cGMP and extended penile erection.
The most common side effects include headache, flushing, dyspepsia, and nasal congestion.
It may also cause color discrimination issues (loss of blue/green discrimination).
Since sildenafil enhances the activity of nitric oxide (NO), it must not be used in conjunction with any products related to organic nitrates.
When used with alpha-adrenergic antagonists (used for alleviating symptoms of benign prostatic hyperplasia), it can produce an additional hypotensive effect; if co-administration is necessary, the patient should be stabilized on a fixed dose of the alpha-adrenergic antagonist before starting sildenafil, beginning with a low dose.
2.
Viartril-S is synthesized from D-glucosamine sulfate and sodium chloride, and is an aminosugar (glucosamine).
Aminosugars are important components of collagen, bone stroma, and para-articular & intra-articular tissues.
The primary use of Viartril-S is to enhance the nutritional function of the joints and promote their metabolism, as well as to improve cartilage and lubrication.
In short, it helps to slow down the degeneration of cartilage.
3.
Clinically, there are very few reports of interactions between these two medications; theoretically, they also have minimal mutual effects.
Of course, if an individual has a unique constitution that leads to adverse reactions, that would be a different matter.
4.
If you have any further questions, please consult your family physician or orthopedic specialist.

Reply Date: 2018/05/06

More Info

Viartril-S, known generically as D-glucosamine sulfate, is a dietary supplement primarily used to support joint health and alleviate symptoms associated with osteoarthritis. It is not classified as a nitrate or a nitric oxide donor, which means it does not belong to the same category of medications as nitroglycerin or other nitrate-based drugs. Therefore, it does not have the same interactions with medications like Viagra (sildenafil) that are contraindicated with nitrates.

Viagra, on the other hand, is a phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction. It works by enhancing the effects of nitric oxide, a natural chemical the body produces that relaxes muscles in the penis, allowing for increased blood flow and an erection in response to sexual stimulation. One of the critical contraindications for Viagra is its interaction with nitrates, which can lead to a dangerous drop in blood pressure.

Given that Viartril-S is not a nitrate, it is generally considered safe to use it in conjunction with Viagra. There are no well-documented interactions between these two medications, and they operate through different mechanisms in the body. Viartril-S focuses on joint health by promoting cartilage repair and reducing inflammation, while Viagra is aimed at improving erectile function.

However, it is essential to consider individual health conditions and any other medications you may be taking. While the combination of Viartril-S and Viagra is not known to cause significant interactions, individual responses to medications can vary. Factors such as underlying health issues, other medications, and overall health status can influence how these drugs work together in your body.

For example, if you have cardiovascular issues or are taking other medications that affect blood pressure, it is crucial to consult with your healthcare provider before starting Viagra. They can provide personalized advice based on your medical history and current health status.

In summary, Viartril-S is not a nitrate and can generally be taken with Viagra without significant concerns for drug interactions. However, it is always advisable to discuss any new medications or supplements with your healthcare provider to ensure safety and efficacy tailored to your specific health needs. If you experience any unusual symptoms or side effects while taking these medications together, seek medical advice promptly.

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