Postpartum Liver Function Concerns: Elevated GOT and ALP Levels - Gastroenterology and Hepatology

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Got got ALP exceeds the standard?


Hello, I recently had a postpartum check-up two and a half months after delivery.
My blood test results showed GOT 43, GPT 46 (normal range is in the 30s), and ALP 100 (normal range is 98).
Abdominal ultrasound was normal, and all other blood tests were normal (no hepatitis B, and previous tests were in the 20s).
Could this be a postpartum effect on the liver enzymes? I do not smoke or drink alcohol, and my lifestyle has been similar to before.
I'm unsure what might be causing this, or if liver enzyme levels naturally fluctuate.
I'm a bit concerned about potential liver issues.

Amy, 30~39 year old female. Ask Date: 2018/05/16

Dr. Chen Qifeng reply Gastroenterology and Hepatology


Abnormal liver function requires further investigation to determine the cause.
Please consult a hepatologist.

Reply Date: 2018/05/16

More Info


Postpartum liver function concerns are quite common, especially for new mothers who may experience various physiological changes after childbirth. Your recent blood test results show elevated levels of GOT (AST) at 43, GPT (ALT) at 46, and ALP at 100, which are slightly above the normal range. It's understandable to feel concerned about these results, especially since you have a history of normal liver function tests prior to pregnancy.

Firstly, it’s important to note that liver function tests can fluctuate for various reasons, and postpartum changes can certainly contribute to this. During pregnancy, the body undergoes significant hormonal and metabolic changes, which can affect liver function. After delivery, it may take some time for your body to return to its pre-pregnancy state, and this can include transient elevations in liver enzymes.

Elevated levels of GOT and GPT can indicate liver inflammation or damage, but they can also be influenced by other factors such as muscle injury, medications, or even physical activity. Since you mentioned that you do not smoke or drink alcohol and that your lifestyle has remained consistent, it’s less likely that lifestyle factors are contributing to the elevation. However, postpartum hormonal changes, stress, and fatigue can also play a role in liver enzyme fluctuations.

ALP (alkaline phosphatase) is another enzyme that can be elevated due to various reasons, including liver, bone, or bile duct issues. In postpartum women, elevated ALP levels can sometimes be attributed to the physiological changes that occur during and after pregnancy, particularly if there was any cholestasis (a condition where bile flow is reduced) during pregnancy.

Given that your abdominal ultrasound results were normal and other blood tests returned to normal ranges, this is a positive sign. It suggests that there may not be any significant underlying liver pathology. However, it is essential to monitor these levels over time. It is not uncommon for liver enzymes to fluctuate, and they may return to normal as your body continues to recover from childbirth.

To address your concerns, I recommend the following steps:
1. Follow-Up Testing: Schedule a follow-up appointment with your healthcare provider to repeat the liver function tests in a few weeks. This will help determine if the elevated levels are persistent or if they return to normal.

2. Monitor Symptoms: Keep an eye on any symptoms that may arise, such as jaundice (yellowing of the skin or eyes), dark urine, light-colored stools, or abdominal pain. If you experience any of these symptoms, seek medical attention promptly.

3. Healthy Lifestyle: Continue to maintain a healthy lifestyle with a balanced diet, regular exercise (as permitted postpartum), and adequate hydration. This can support liver health and overall recovery.

4. Discuss Medications: If you are taking any medications or supplements, discuss them with your healthcare provider to ensure they are not contributing to elevated liver enzymes.

5. Stress Management: Postpartum can be a stressful time, and managing stress through relaxation techniques, support groups, or counseling can be beneficial for both mental and physical health.

In conclusion, while elevated liver enzymes can be concerning, they are not uncommon in the postpartum period. With appropriate follow-up and monitoring, you can gain a clearer understanding of your liver health. Always consult with your healthcare provider for personalized advice and recommendations based on your specific situation.

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