the Impact of DEANXIT and Tramadol on Sexual Function - Pharmacology

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Medication Consultation for Erectile Dysfunction


DEANXIT DRAGEES 10MG and Tramadol 37.5 mg + Acetaminophen 325 mg are both medications that may have an impact on sexual function.
The package insert for DEANXIT indicates that erectile dysfunction is listed as an unknown side effect, while studies in rats have shown significant effects.
Similarly, the combination of Tramadol 37.5 mg + Acetaminophen 325 mg also mentions the potential for erectile dysfunction.
Both of these medications, being opioids, can inhibit sexual nerve function.
Therefore, it is possible that both medications could contribute to sexual dysfunction.

Li, 30~39 year old female. Ask Date: 2018/06/16

Dr. Hong Kunyi reply Pharmacology


Hello Mr.
Lee: DEANXIT DRAGEES 10MG is a combination medication that incorporates two drugs, providing properties such as antidepressant effects, anxiety relief, and stimulation of mental activity.
When used within the reasonable dosage prescribed by a physician, this medication has very few side effects, with occasional reports of restlessness and insomnia being temporary.
There have been reports of erectile dysfunction associated with DEANXIT DRAGEES 10MG; if you experience severe erectile dysfunction, it is advisable to discuss with your prescribing physician whether to reduce the dosage or discontinue the medication, as these effects can be reversed after stopping the medication.

Additionally, Tramadol 37.5 mg + Acetaminophen 325 mg is a combination analgesic, with the most common side effects occurring in the central nervous system and gastrointestinal system.
The most frequently reported adverse reactions include nausea, dizziness, and drowsiness.
Less common side effects related to psychiatric disturbances include memory loss, depersonalization, depression, substance abuse, emotional instability, hallucinations, erectile dysfunction, nightmares, and abnormal thinking; therefore, erectile dysfunction is not commonly associated with this combination analgesic.
I hope this information addresses your concerns, and I wish you good health and happiness.

Reply Date: 2018/06/16

More Info


The impact of medications like DEANXIT DRAGEES and Tramadol on sexual function is a significant concern for many patients. Both of these medications have been associated with sexual side effects, including erectile dysfunction (ED) and other forms of sexual dysfunction.

DEANXIT DRAGEES is a combination medication that typically contains an antidepressant and an anxiolytic. While it is primarily used to treat anxiety and depression, there are reports of sexual side effects, including erectile dysfunction. The mechanism behind this could be related to the medication's effects on neurotransmitters in the brain that are involved in sexual arousal and function. Antidepressants, particularly those that affect serotonin levels, can lead to sexual side effects due to their impact on libido and erectile function. In some cases, these effects may be temporary and resolve after discontinuation of the medication.

On the other hand, Tramadol is an opioid analgesic that is often prescribed for pain relief. It has a dual mechanism of action, affecting both opioid receptors and inhibiting the reuptake of norepinephrine and serotonin. While Tramadol is effective for pain management, it is also associated with sexual side effects, including erectile dysfunction and decreased libido. The opioid component of Tramadol can lead to hormonal changes that may negatively impact sexual function, including reduced testosterone levels, which is crucial for male sexual health.

The concern regarding both medications is valid, especially considering that they can both influence sexual function through different pathways. In animal studies, Tramadol has been shown to have effects on sexual behavior, and while human studies may not always replicate these findings, the potential for sexual dysfunction exists.
It is important to note that the occurrence of erectile dysfunction as a side effect can vary from person to person. Some individuals may experience significant sexual side effects, while others may not notice any changes. Factors such as dosage, duration of use, individual physiology, and the presence of other health conditions can all play a role in how these medications affect sexual function.

If a patient experiences erectile dysfunction or other sexual side effects while taking DEANXIT or Tramadol, it is crucial to discuss these concerns with a healthcare provider. Adjustments to the medication regimen, such as dosage changes or switching to alternative medications with a lower risk of sexual side effects, may be necessary. In some cases, additional treatments for erectile dysfunction may be considered.

In conclusion, both DEANXIT DRAGEES and Tramadol can potentially impact sexual function, leading to issues such as erectile dysfunction. Understanding the side effects of these medications is essential for managing patient care effectively. If you or someone you know is experiencing these side effects, it is advisable to seek medical advice to explore possible solutions and adjustments to the treatment plan.

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