Struggling with Medication Side Effects: Insomnia and Anxiety Issues - Psychiatry

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Troubled by the side effects of medication?


Dear Doctor,
Can taking Olanzapine lead to insomnia? I have been on it for six months, and my sleep issues have been worsening.
I have difficulty falling asleep and experience unexplained tremors.
Even with sleeping pills, I can only sleep for 1 to 2 hours.
I am also concerned about becoming dependent on sleeping medications.
Recently, due to my sleep disturbances, I feel fatigued during the day, and at night, I can't fall asleep.
I don't know what to do.
Can I stop the medication? It seems that the longer I take it, the more side effects I experience...

Xiao Zi, 20~29 year old female. Ask Date: 2018/07/19

Dr. Cai Qijin reply Psychiatry


Hello: A small number of individuals may experience insomnia when taking Anxiolytics before bedtime, so it may be advisable to consider taking it in the morning instead.
Sleep issues could also be a result of an underlying mental health condition, so it is recommended to discuss medication adjustments with a psychiatrist.

Reply Date: 2018/07/19

More Info


It sounds like you're experiencing a challenging situation with your medication, particularly with insomnia and anxiety. Let's break down your concerns regarding the medication you mentioned, which I assume refers to Olanzapine (known as Zyprexa in the U.S.), a medication commonly used to treat conditions like schizophrenia and bipolar disorder, and sometimes for severe anxiety or depression.

1. Insomnia and Medication Side Effects: Olanzapine can indeed have a range of side effects, and while it is often prescribed to help with sleep due to its sedative properties, some individuals may experience paradoxical effects, including insomnia or restlessness. This can be particularly frustrating, especially if you are relying on sleep medications to help you rest. The phenomenon of experiencing increased anxiety or insomnia while on a medication that is supposed to help can occur, and it is essential to communicate these symptoms to your prescribing physician.

2. Physical Symptoms: The "shaking" or tremors you mentioned could be a side effect of the medication or a symptom of anxiety itself. Medications like Olanzapine can sometimes lead to extrapyramidal symptoms (EPS), which include tremors, rigidity, and other movement disorders. It's crucial to discuss these symptoms with your doctor, as they may need to adjust your dosage or consider alternative treatments.

3. Dependence on Sleep Medications: Your concern about becoming dependent on sleep medications is valid. Long-term use of benzodiazepines or other sedative-hypnotics can lead to tolerance, meaning you may need higher doses to achieve the same effect, and withdrawal symptoms can occur if you suddenly stop taking them. It’s advisable to work closely with your healthcare provider to develop a tapering plan if you decide to discontinue these medications.

4. Sleep Hygiene and Non-Pharmacological Approaches: In addition to medication management, incorporating good sleep hygiene practices can significantly improve your sleep quality. This includes maintaining a regular sleep schedule, creating a comfortable sleep environment, avoiding caffeine and heavy meals before bedtime, and engaging in relaxation techniques such as mindfulness or deep breathing exercises.

5. Consulting Your Doctor: Before making any changes to your medication regimen, it’s crucial to consult with your healthcare provider. They can assess your current situation, consider the potential benefits and risks of continuing or discontinuing Olanzapine, and explore alternative treatments that may be more suitable for your needs. This could include adjusting your current medications, switching to a different class of medications, or integrating therapy options like cognitive-behavioral therapy (CBT) for insomnia.

6. Potential Alternatives: If Olanzapine is not working for you, your doctor may consider other medications that can help with both anxiety and sleep without the same level of side effects. Options such as certain antidepressants (like trazodone) or non-benzodiazepine sleep aids (like zolpidem or eszopiclone) might be explored, depending on your specific symptoms and medical history.

In summary, it’s essential to have an open dialogue with your healthcare provider about your symptoms and concerns. They can help you navigate the complexities of your treatment plan and find a solution that works best for you. Remember, you are not alone in this, and many people face similar challenges with medications and sleep issues.

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