Can You Take Erythromycin and Cephalexin Together Safely? - Family Medicine

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Can I take Erythromycin 0.25 mg and Cephalexin 500 mg together? Are there any side effects from taking them together?

NinA, 20~29 year old female. Ask Date: 2018/07/21

Dr. Liao Yaopan reply Family Medicine


Hello, please be reminded that online consultations are not equivalent to in-person medical visits and cannot provide diagnoses or treatment recommendations.
It is advisable to discuss with your prescribing physician.
Changhua Hospital cares about you.

Reply Date: 2018/07/21

More Info


When considering the simultaneous use of Erythromycin and Cephalexin, it is essential to understand the pharmacological properties of both medications and their potential interactions. Erythromycin is a macrolide antibiotic that works by inhibiting bacterial protein synthesis, while Cephalexin is a cephalosporin antibiotic that disrupts bacterial cell wall synthesis. Both are commonly used to treat various bacterial infections, but they belong to different classes of antibiotics.

Based on current medical literature and drug interaction databases, there are no significant interactions reported between Erythromycin and Cephalexin. This means that, in general, it is considered safe to take these two antibiotics together. However, it is crucial to monitor for any unusual side effects or reactions, as individual responses to medications can vary.

One of the primary concerns when taking multiple medications is the potential for increased side effects. Both Erythromycin and Cephalexin can cause gastrointestinal disturbances, such as nausea, vomiting, and diarrhea. When taken together, there is a possibility that these side effects may be exacerbated. Therefore, it is advisable to take these medications with food to minimize gastrointestinal discomfort.

Additionally, both antibiotics can affect the liver, although Erythromycin is more notorious for its potential to cause liver enzyme elevations. If you have pre-existing liver conditions or are taking other medications that affect liver function, it is essential to consult your healthcare provider before starting this combination.

Another consideration is the potential for antibiotic resistance. Using multiple antibiotics can sometimes lead to an imbalance in the normal flora of the gut, which may contribute to the development of resistant bacterial strains. Therefore, it is crucial to use antibiotics judiciously and only when necessary.

If you are prescribed both Erythromycin and Cephalexin, it is essential to follow your healthcare provider's instructions regarding dosage and duration of treatment. Do not hesitate to reach out to your healthcare provider if you experience any adverse effects or if you have concerns about taking these medications together.

In summary, while Erythromycin and Cephalexin can generally be taken together safely, it is essential to be aware of potential side effects and to monitor your health closely during treatment. Always consult your healthcare provider for personalized advice and guidance based on your specific health situation.

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