Do Birth Control Pills Interact with Antibiotics Like Cephalexin? - Pharmacology

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Do birth control pills interact with antibiotics?


I have been taking Yaz birth control pills and recently experienced mild urethritis, so my doctor prescribed Cephalexin, an antibiotic.
I would like to know if there are any interactions between Yaz and this antibiotic.

Ms. Zheng, 20~29 year old female. Ask Date: 2017/02/06

Dr. Hou Fangmin reply Pharmacology


Hello: The components of the contraceptive pill Yuzhi are Ethinyl Estradiol and Drospirenone.
The interaction with Cephalexin has been verified to show no interactions.
However, it is important to note that consuming coffee and grapefruit juice may increase central nervous system stimulation and elevate hormone levels.
Wishing you peace and joy.

Reply Date: 2017/02/06

More Info


When it comes to the interaction between birth control pills and antibiotics, particularly Cephalexin, it is important to understand the nuances involved. Based on current medical knowledge and guidelines, Cephalexin, which is a cephalosporin antibiotic, does not have a significant interaction with most hormonal contraceptives, including the birth control pill you mentioned, which is known as "Yaz" (悅姿).

Historically, there has been concern regarding certain antibiotics and their potential to reduce the effectiveness of birth control pills. This concern primarily stems from the interaction of some antibiotics, particularly rifampin and rifabutin, which are known to induce liver enzymes that can metabolize contraceptive hormones more quickly, potentially leading to reduced efficacy of the birth control method. However, Cephalexin does not share this property and is not known to affect the metabolism of hormonal contraceptives in the same way.

In your case, taking Yaz while also being prescribed Cephalexin for a urinary tract infection (UTI) should not compromise the effectiveness of your birth control. It is always advisable to take your medications as prescribed and to continue using your birth control method consistently. If you are concerned about the possibility of breakthrough bleeding or any other side effects, it is a good idea to discuss these with your healthcare provider.

Additionally, while the risk of interaction is low, it is always prudent to be aware of your body and any changes that may occur during this time. If you experience any unusual symptoms or have concerns about your contraceptive effectiveness, do not hesitate to reach out to your healthcare provider for personalized advice.

In summary, based on the current understanding of drug interactions, taking Yaz and Cephalexin together should not pose a risk to the effectiveness of your birth control. However, maintaining open communication with your healthcare provider is key to managing your health effectively, especially when dealing with multiple medications. Always ensure that you are following the prescribed regimen for both your antibiotic and your birth control pill, and monitor for any side effects or changes in your health status.

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