Concerns Over Weight Loss and Treatment Efficacy in TB Patients - Pulmonology

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No improvement observed after tuberculosis treatment; significant weight loss?


Hello Dr.
Huang, I am a Taiwanese working in the Philippines, and I am inquiring on behalf of a Filipino friend who has been diagnosed with tuberculosis (TB).
My friend is a 26-year-old male who started coughing around May of this year.
Initially, he thought it was just a common cold and did not pay much attention to it.
After two to three months, he went to the local municipal hospital in mid-July and was confirmed to have TB.
He began taking medication regularly starting August 2.
However, as of today, August 19, it has been over two weeks, and I have come across some articles stating that if medication is taken on time, improvement usually begins, and the TB bacteria should become non-infectious after two weeks.

Unfortunately, my friend's current condition has worsened; after starting the medication, he began experiencing nausea when eating and has lost a significant amount of weight, dropping from 65 kg to currently in the 40s, losing over 20 kg in total.
I am unsure if this is a side effect of the medication affecting his gastrointestinal system, but he has been so afraid of vomiting that he is only eating plain toast.
I visited him today and was shocked by his drastic weight loss, so I have started asking his family to ensure he is fed at least one bottle of nutritional supplement with each meal.
He was previously able to move around freely but is now confined to his bed, struggling even to sit up, and has been experiencing symptoms of shaking, sweating, and chills.
I am particularly concerned because a friend of his passed away six months ago from TB after being on medication for less than three months.
That friend also experienced severe weight loss, nearly to the point of being skin and bones.
Since my current friend visited the deceased friend, I am worried he may have contracted the disease as well.
I urgently need your assistance, so I would like to ask you the following questions:
1.
How long after starting medication should he return for a follow-up appointment? The local doctor has only scheduled a follow-up in one month, but I fear that my friend's condition may worsen if he waits that long.
2.
Is it normal for someone with tuberculosis to experience such significant weight loss after starting treatment?
3.
It has been over two weeks since he started the medication, and aside from his drastic weight loss, his cough, chest pain, and mental state have not improved.
Could this indicate drug-resistant tuberculosis?
4.
I am considering whether the treatment here is inadequate and if transferring him to Taiwan for treatment might provide better care.
If that is possible, would the necessary medications need to be paid out-of-pocket since he is a foreigner?
I apologize for the lengthy message, but I truly need your assistance.
Thank you very much.

Ahn, 30~39 year old female. Ask Date: 2018/08/20

Dr. Huang Yiwen reply Pulmonology


Dear Ahn: I apologize for the delayed response.
Here are the answers to your four questions:
1.
Generally, after starting medication, a follow-up visit is required within a week to assess any issues related to the treatment.
If there are any problems, please return for a consultation without waiting for the scheduled appointment with the physician.

2.
This is abnormal; there may be other underlying issues.
Please conduct a thorough evaluation of any additional problems.

3.
It is possible; please continue to monitor the sputum and perform rapid microbiological testing.

4.
Seeking medical treatment in Taiwan may involve visa issues.
Changhua Hospital is concerned about you.

Reply Date: 2018/08/20

More Info


It sounds like your friend is experiencing a very challenging situation with tuberculosis (TB) treatment, and your concerns are valid. Let’s address your questions and provide some additional context regarding TB treatment and management.

1. Follow-Up Appointments: Typically, patients undergoing TB treatment should have follow-up appointments within the first month of starting therapy. This is crucial for monitoring the patient's response to treatment and managing any side effects. In your friend's case, given the significant weight loss and other concerning symptoms, it would be advisable to seek medical attention sooner rather than waiting for the scheduled appointment in a month. If possible, he should return to the healthcare provider or seek a second opinion to ensure that his treatment is being appropriately managed.

2. Weight Loss: Rapid and significant weight loss, such as the 20 kg loss your friend has experienced, is not typical during the initial phase of TB treatment. While some weight loss can occur due to the illness itself, such drastic changes often indicate that there may be other underlying issues, such as severe side effects from the medication or complications from the disease. It’s essential to evaluate his nutritional intake and consider dietary supplements, as you mentioned, to help stabilize his condition.

3. Lack of Improvement: The persistence of symptoms like cough, chest pain, and mental distress after two weeks of treatment raises concerns about the effectiveness of the current regimen. It could suggest the possibility of drug-resistant TB, especially if he is not responding to standard first-line medications. A sputum test or other diagnostic evaluations should be conducted to assess the presence of drug-resistant strains and to adjust the treatment plan accordingly.

4. Transfer to Taiwan for Treatment: Transferring your friend to Taiwan for treatment could provide access to more comprehensive healthcare services. However, it is crucial to consider the logistics, including visa requirements and the potential costs involved. In Taiwan, TB treatment is generally covered by the National Health Insurance, but there may be additional costs for non-residents. It would be best to consult with healthcare providers in Taiwan to understand the specifics of treatment options and costs for foreign patients.

In addition to these points, it’s important to recognize that TB treatment can be complex and requires a multidisciplinary approach. Support from healthcare professionals, including nutritionists, can be beneficial in managing side effects and ensuring adequate nutritional support. Furthermore, psychological support may also be necessary, as the mental toll of dealing with a serious illness can be significant.

In summary, your friend's situation is concerning, and immediate medical attention is warranted. Encourage him to seek help from healthcare professionals who can provide a thorough evaluation and adjust his treatment plan as needed. The goal is to ensure that he receives the appropriate care to manage his TB effectively and improve his overall health.

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