Breast fibrocystic changes
This year, I underwent a breast core needle biopsy at the hospital, and the doctor informed me that the result is a benign fibrocystic change.
There is no need to worry, and I only need to follow up once a year.
Below is the imaging pathology report I retrieved from my health record; could you please explain what it means?
The specimen consists of two tissue cores measuring up to 1.5 x 0.2 x 0.2 cm, fixed in formalin.
Grossly, they are gray and soft.
All sections were examined.
Microscopically, one tissue shows fibroadipose tissue.
Another tissue shows a picture of fibrotic breast with focal columnar cell change and intraluminal microcalcifications.
Immunohistochemistry for estrogen receptor (ER) shows heterogeneity, and cytokeratin 5/6 (CK5/6) demonstrates mosaic staining patterns.
yue, 50~59 year old female. Ask Date: 2018/10/08
Dr. Tang Yuxiong reply Surgery
Hello, the interpretation of any pathology report should be accompanied by imaging and clinical diagnosis.
Since I cannot see the relevant breast imaging you have undergone, I cannot make a judgment based solely on the report's wording.
I recommend that you continue with outpatient follow-up and discuss this with your physician.
Thank you.
Reply Date: 2018/10/08
More Info
Understanding your benign fibrocystic breast condition can be a source of concern, but it's important to remember that benign conditions like fibrocystic changes are quite common and usually not a cause for alarm. Based on the information you provided from your pathology report, let's break down what it means and how it relates to your health.
What is a Benign Fibrocystic Breast Condition?
Benign fibrocystic breast conditions, often referred to as fibrocystic breast disease, are characterized by the presence of fibrous tissue and cysts in the breast. These changes are influenced by hormonal fluctuations, particularly estrogen and progesterone, and are most commonly seen in women of reproductive age. Symptoms may include breast tenderness, lumpiness, and changes in breast tissue that can vary with the menstrual cycle.
Understanding Your Pathology Report
Your report indicates that the specimen consists of two tissue cores measuring up to 1.5 x 0.2 x 0.2 cm, which were fixed in formalin for analysis. The description of the tissue as "grey and soft" is typical for fibrocystic changes, which often present with a softer texture compared to more solid tumors.
1. Fibroadipose Tissue: This term refers to a combination of fibrous and fatty tissues, which is a normal component of breast tissue. The presence of fibroadipose tissue suggests that the sample contains typical breast tissue, which is a reassuring sign.
2. Fibrotic Breast with Focal Columnar Cell Change: This indicates that there are areas of fibrosis (thickening and scarring of connective tissue) in the breast tissue. Columnar cell change refers to alterations in the cells lining the ducts of the breast, which can occur in response to hormonal changes. While these changes are benign, they may warrant monitoring.
3. Intraluminal Microcalcifications: These are tiny deposits of calcium that can occur within the ducts of the breast. While microcalcifications can sometimes be associated with malignancy, in the context of fibrocystic changes, they are often benign. However, they may require follow-up imaging to ensure they do not change over time.
4. Immunohistochemistry Findings:
- ER (Estrogen Receptor) Heterogeneity: This means that the estrogen receptors are present in varying amounts in different areas of the tissue. This finding can be common in benign conditions and does not indicate cancer.
- CK5/6 Mosaic Staining Patterns: This refers to the presence of certain proteins in the cells, which can help characterize the type of cells present. Mosaic staining patterns typically indicate a mix of different cell types, which is often seen in benign conditions.
Follow-Up and Management
Given that your doctor has indicated that the findings are benign and that you will need to follow up once a year, this is a standard approach for managing benign fibrocystic changes. Regular monitoring allows for the observation of any changes in the breast tissue over time. It is essential to maintain open communication with your healthcare provider and report any new symptoms, such as changes in breast lumps, persistent pain, or any unusual discharge.
Conclusion
In summary, your pathology report indicates benign fibrocystic changes in your breast tissue, which are common and typically not a cause for concern. The presence of fibroadipose tissue, columnar cell changes, and microcalcifications, along with the immunohistochemical findings, all point towards a benign condition. Regular follow-up is crucial, and you should feel reassured that you are under appropriate medical care. If you have any further questions or concerns, do not hesitate to reach out to your healthcare provider for more personalized advice.
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