Delayed Bone Healing: Causes and Symptoms of Infection - Orthopedics

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Bone callus has not formed?


Hello, I sustained a comminuted fracture of the distal third of the tibia and fibula on August 31, and I underwent a self-funded surgery involving two steel plates and approximately 21 screws.
Now, nearly eight weeks later, I returned for a follow-up X-ray, and the doctor mentioned that there is no evidence of callus formation, which is somewhat slow for my age.
I do not smoke or drink alcohol.
I would like to know if it is possible that an infection is preventing callus formation? If there is an infection, what symptoms should I look for?

HY, 30~39 year old female. Ask Date: 2018/10/25

Dr. Shi Guozheng reply Orthopedics


At eight weeks, it is still not possible to determine whether there is healing callus formation.
Comminuted fractures typically heal more slowly.
If there is a bacterial infection, the skin may show wounds or pus may be present, which requires close monitoring.
If there is no callus formation after six months to a year, further treatment may be necessary.

Reply Date: 2018/10/25

More Info


Delayed bone healing, particularly in the context of fractures, can be a significant concern for patients recovering from surgical interventions. In your case, with a complex fracture of the tibia and fibula, the absence of bone callus formation after eight weeks post-surgery raises valid questions about potential underlying issues, including infection.


Causes of Delayed Bone Healing
1. Infection: One of the most critical factors that can impede bone healing is infection, particularly osteomyelitis, which is an infection of the bone. If bacteria invade the surgical site or the bone itself, they can cause inflammation and disrupt the healing process.
2. Poor Blood Supply: Adequate blood flow is essential for bone healing. Any condition that compromises blood circulation, such as peripheral vascular disease or diabetes, can lead to delayed healing.

3. Nutritional Deficiencies: Essential nutrients, particularly calcium and vitamin D, play a vital role in bone health. A deficiency in these nutrients can slow down the healing process.

4. Mechanical Factors: If the fracture site is subjected to excessive movement or stress, it may not heal properly. This is particularly relevant if the fixation devices (like plates and screws) are not providing adequate stability.

5. Age and Comorbidities: Older age and underlying health conditions (like osteoporosis or chronic illnesses) can also contribute to slower healing times.


Symptoms of Infection
If an infection is present, you may experience several symptoms, including:
- Localized Pain: Increased pain at the fracture site, which may worsen over time.

- Swelling and Redness: The area around the fracture may become swollen, red, and warm to the touch.

- Fever: A systemic response to infection may manifest as a fever or chills.

- Discharge: Pus or other discharge from the surgical site may indicate an infection.

- Delayed Healing: As you noted, the lack of bone callus formation can also be a sign of infection.


Next Steps
Given your situation, it is crucial to follow up with your orthopedic surgeon. They may recommend further imaging studies, such as an MRI or a CT scan, to assess for signs of infection or other complications. Blood tests, including inflammatory markers (like C-reactive protein or ESR), can also help determine if an infection is present.

If an infection is confirmed, treatment typically involves antibiotics and possibly surgical intervention to clean the infected area and remove any necrotic tissue.

Conclusion
In summary, while the absence of bone callus formation after eight weeks can be concerning, it is essential to consider various factors, including the possibility of infection. Monitoring for symptoms of infection and maintaining open communication with your healthcare provider is vital for addressing any complications that may arise. Early intervention can significantly improve outcomes and facilitate a more effective healing process.

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