Propranolol Side Effects: Tremors and Limb Weakness - Neurology

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Tremors and intermittent weakness in the limbs?


A few days ago, I went for an examination due to mild hand tremors and was prescribed 309 Propranolol (Inderal) to take twice daily.
I have been taking it for over three weeks now, but I am experiencing hand tremors, weakness in my limbs (which is very distressing and makes it difficult to concentrate), and increased fatigue.
I would like to know if these symptoms are normal side effects of the medication or if Propranolol does not typically cause these issues.
Specifically, can this medication cause numbness, tingling, or weakness in the limbs? Should I consider stopping the medication due to these side effects?

Y Qian, 30~39 year old female. Ask Date: 2018/11/07

Dr. Jiang Junyi reply Neurology


Hello: Based on your description, propranolol is primarily a sympatholytic agent.
It has shown good therapeutic effects for essential tremors or tremors caused by emotional stress.
However, due to potential side effects from decreased heart rate and blood pressure, such as fatigue, drowsiness, bradycardia, and abnormal skin sensations in the hands, it is important to monitor for more severe symptoms like dizziness, insomnia, palpitations, AV block, or bronchospasm.
If the tremors are responding to treatment, it is advisable to consider reducing the dosage to minimize side effects.
I recommend discussing any adjustments to your medication with your primary care physician.
Wishing you good health and peace.
Dr.
Jiang, Neurology Department, Tao Medical Center, cares about you.

Reply Date: 2018/11/07

More Info


Propranolol is a non-selective beta-adrenergic antagonist commonly used to treat various conditions, including hypertension, anxiety, and certain types of tremors. While it is generally well-tolerated, like any medication, it can have side effects. The symptoms you describe—tremors, limb weakness, and fatigue—are indeed concerning and warrant further discussion.

Firstly, it is important to understand that propranolol can cause a range of side effects. Commonly reported side effects include fatigue, dizziness, and gastrointestinal disturbances. However, the symptoms you are experiencing—specifically tremors and limb weakness—are less common and may indicate that the medication is not well-suited for you or that the dosage may need adjustment.

Tremors can occur as a paradoxical effect in some individuals taking propranolol, especially if they have underlying conditions that predispose them to tremors, such as anxiety or essential tremor. In some cases, propranolol is actually used to treat tremors, but it can also exacerbate them in certain individuals. Limb weakness and fatigue can also be side effects of propranolol, particularly if the body is adjusting to the medication or if the dosage is too high for the individual.

Regarding the sensations of numbness, tingling, or weakness in the limbs, these are not typical side effects of propranolol. Such symptoms could indicate other underlying issues, such as peripheral neuropathy or vascular problems, which may need to be evaluated separately. It is crucial to differentiate whether these symptoms are a direct result of the medication or if they stem from another medical condition.

If you are experiencing significant discomfort or if these symptoms are impacting your ability to function, it is advisable to consult your healthcare provider promptly. They may recommend adjusting the dosage, switching to a different medication, or conducting further tests to rule out other potential causes of your symptoms. It is generally not advisable to stop taking a medication like propranolol abruptly without medical guidance, as this can lead to rebound effects, especially if you are using it to manage heart rate or blood pressure.

In summary, while propranolol can cause side effects such as fatigue and dizziness, the specific symptoms of tremors, limb weakness, and fatigue you are experiencing are concerning and should be discussed with your healthcare provider. They can help determine whether these symptoms are related to the medication or if there is another underlying issue that needs to be addressed. Always prioritize open communication with your healthcare team to ensure safe and effective management of your health conditions.

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