Does Doxycycline Affect the Effectiveness of Birth Control Pills? - Obstetrics and Gynecology

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Oral contraceptives


Hello, doctor.
I am currently taking oral contraceptives and have not been pregnant for 6 months.
Recently, I visited a dermatologist who prescribed two types of antibiotics: doxycycline enteric and ningilon capsules.
After taking them for a few days, I started experiencing slight bleeding.
Will this affect the efficacy of the contraceptive pills? I did not have this issue in the previous months.
Thank you.

Alice, 20~29 year old female. Ask Date: 2018/11/23

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, it generally does not have an impact.
You can continue taking the oral contraceptive pills and just monitor the situation.
Wishing you good health.

Reply Date: 2018/11/23

More Info


Doxycycline is a tetracycline antibiotic that is commonly used to treat various bacterial infections. It is classified as a Category D medication during pregnancy, which means there is evidence of risk to the fetus based on human data. However, when it comes to its interaction with hormonal contraceptives, the situation is a bit more nuanced.

Generally, Doxycycline is not known to significantly affect the effectiveness of birth control pills. Unlike some other antibiotics, such as rifampin, which can induce liver enzymes and reduce the effectiveness of hormonal contraceptives, Doxycycline does not have this effect. The primary concern with Doxycycline is its potential side effects, such as gastrointestinal disturbances, which could theoretically lead to decreased absorption of the contraceptive if vomiting or diarrhea occurs shortly after taking the pill.

In your case, you mentioned experiencing light bleeding after starting Doxycycline while on birth control pills. This could be attributed to several factors unrelated to the antibiotic itself. Breakthrough bleeding can occur for various reasons, including hormonal fluctuations, stress, changes in routine, or even the introduction of a new medication. It is essential to consider that the body may react differently to medications, and the introduction of Doxycycline could be coincidental rather than causative.

If you have been taking your birth control pills consistently and correctly, the likelihood of Doxycycline affecting their effectiveness is low. However, if you are experiencing unusual bleeding or any other side effects, it is crucial to consult with your healthcare provider. They can assess your situation more thoroughly and determine if any adjustments to your medication regimen are necessary.

In addition, if you are concerned about the potential interactions between Doxycycline and your birth control, you might want to discuss alternative antibiotics with your healthcare provider. There are many options available that do not have any known interactions with hormonal contraceptives.

In summary, while Doxycycline is not expected to interfere with the effectiveness of birth control pills, it is always best to communicate openly with your healthcare provider about any concerns or side effects you experience. They can provide personalized advice and ensure that you are using the most effective and safe treatment options for your needs. Remember, maintaining consistent communication with your healthcare provider is key to managing your health effectively.

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