Drug Interactions: Oral Contraceptives and Coenzyme Q10 Supplements - Pharmacology

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Drug Interactions - Oral Contraceptives and Coenzyme Q10 Collagen Complex Nutritional Tablets


Hello, Pharmacist Chen.
I have been taking Bayer's Yasmin for many years due to irregular menstrual cycles.
Recently, I am considering adding a nutritional supplement, but I am unsure if it will have any effects.
The supplement I want to purchase is Kirkland Signature Coenzyme Q10 Collagen Complex, which contains the following ingredients: microcrystalline cellulose, vitamin C (ascorbic acid), collagen (from chicken cartilage), soybean extract, vitamin E (d-alpha tocopheryl acetate), gelatin (from fish), calcium silicate, silicon dioxide, cross-linked carboxymethyl cellulose sodium, coenzyme Q10, magnesium stearate, and the coating is made of hydroxypropyl methylcellulose and glycerin.
It is noted that it should not be taken with the anticoagulant medication warfarin.
Thank you.

cc, 30~39 year old female. Ask Date: 2018/12/25

Dr. Chen Yuemei reply Pharmacology


Hello: According to the database, the medication Yejih (active ingredients: drospirenone and ethinyl estradiol) has a moderate interaction with caffeine found in food, which may increase central nervous system stimulation.
There are no other related reports.

Reply Date: 2018/12/25

More Info


When considering the potential interactions between oral contraceptives, such as Yasmin, and dietary supplements like Coenzyme Q10 (CoQ10), it is essential to understand the pharmacological properties of each substance. Yasmin is a combination oral contraceptive that contains ethinyl estradiol and drospirenone, which work together to prevent ovulation and regulate menstrual cycles. CoQ10, on the other hand, is a naturally occurring antioxidant that plays a crucial role in energy production within cells and is often taken as a supplement for various health benefits, including cardiovascular health and energy enhancement.

From a pharmacological standpoint, there are no well-documented interactions between CoQ10 and the components of Yasmin. CoQ10 is not known to affect the efficacy of hormonal contraceptives. In fact, some studies suggest that CoQ10 may have a positive effect on overall health, potentially supporting cardiovascular function and reducing oxidative stress, which could be beneficial for individuals taking hormonal medications.

However, it is crucial to consider the formulation of the supplement you are interested in. The Kirkland Signature CoQ10 supplement you mentioned contains various ingredients, including collagen, vitamin C, and vitamin E. While these components are generally safe and well-tolerated, it is important to ensure that none of them interact negatively with Yasmin. For instance, vitamin E can have anticoagulant effects, but at typical dietary supplement doses, it is unlikely to pose a significant risk when taken alongside Yasmin.

One important note is the warning against taking CoQ10 with anticoagulants like warfarin. This is because CoQ10 may potentially reduce the effectiveness of warfarin, leading to an increased risk of clotting. However, since you are not taking warfarin, this concern does not apply to your situation.

In summary, taking CoQ10 supplements while on Yasmin is generally considered safe and should not interfere with the contraceptive's effectiveness. However, it is always advisable to consult with your healthcare provider before starting any new supplement, especially if you have underlying health conditions or are taking other medications. Your healthcare provider can provide personalized advice based on your health history and current medications.

Additionally, it is essential to monitor your body's response to the new supplement. If you experience any unusual symptoms or side effects after starting CoQ10, you should report these to your healthcare provider. Regular check-ins with your doctor can help ensure that your contraceptive method remains effective and that your overall health is supported by any supplements you choose to take.

In conclusion, while there is no significant evidence to suggest that CoQ10 will interfere with the effectiveness of Yasmin, maintaining open communication with your healthcare provider is key to safely managing your health and any supplements you may wish to incorporate into your routine.

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