Syphilis Recurrence: Symptoms and Treatment Concerns - Urology

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Uncertainty about whether syphilis has recurred?


Hello doctor, I had my first episode around January 2017, and it wasn't until February 2018 that I received injection treatment.
In August of the same year, I noticed an increase in my levels, so I received three additional injections.
However, around December, I discovered a small amount of eczema around my anus.
Is this a recurrence? Is there a possibility that my body will develop resistance to penicillin (I had unprotected intercourse 1 to 3 times in between)?

Xiang, 20~29 year old female. Ask Date: 2019/01/01

Dr. Chen Jiansheng reply Urology


Blood tests are necessary to determine.

Reply Date: 2019/01/01

More Info


Syphilis, a sexually transmitted infection caused by the bacterium Treponema pallidum, can indeed recur after initial treatment, especially if the infection was not completely eradicated or if there was re-exposure to the bacteria. Your situation raises several important points regarding the recurrence of syphilis, its symptoms, and treatment concerns.

Firstly, it is essential to understand the stages of syphilis. The primary stage typically presents with a painless sore (chancre) at the site of infection, while the secondary stage may involve systemic symptoms such as rashes, fever, and swollen lymph nodes. If left untreated, syphilis can progress to latent and tertiary stages, which can have severe health consequences. The symptoms you describe, such as the presence of eczema around the anal area, could potentially indicate a recurrence or a new infection, especially considering your history of unprotected sexual encounters.

Regarding your treatment history, it is crucial to ensure that the treatment was adequate. Benzathine penicillin G is the standard treatment for syphilis, and the number of doses depends on the stage of the disease. If you received the appropriate treatment but still experience symptoms, it could suggest either treatment failure or reinfection. It is also important to note that while the body does not typically develop resistance to penicillin, the risk of reinfection remains high if exposed again.

In your case, the resurgence of symptoms after treatment could indicate a few possibilities:
1. Reinfection: If you engaged in unprotected sexual activities after your initial treatment, it is possible to contract syphilis again from an infected partner.

2. Inadequate Treatment: If the treatment was not administered correctly or if there were issues with the dosage or timing, it might not have fully cleared the infection.

3. Immune Response: Sometimes, the body may react to the remnants of the bacteria or other infections, leading to symptoms that mimic a recurrence.

To address your concerns about developing antibiotic resistance, it is important to clarify that penicillin is generally very effective against syphilis, and resistance is not a common issue. However, the risk of reinfection remains a significant concern, particularly if safe sex practices are not consistently followed.

Given your symptoms and history, it is advisable to consult a healthcare provider for further evaluation. They may recommend:
- Serological Testing: Blood tests to check for syphilis antibodies and determine if the infection is active.

- Physical Examination: A thorough examination of the affected area to assess for any lesions or signs of infection.

- Follow-up Treatment: If reinfection or treatment failure is suspected, additional doses of penicillin or alternative treatments may be necessary.

In conclusion, while syphilis can recur, it is essential to differentiate between a true recurrence and other potential issues. Engaging in safe sexual practices, including the use of condoms, can significantly reduce the risk of reinfection. Regular follow-ups with your healthcare provider are crucial to monitor your health and manage any potential complications effectively.

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