Doxycycline Side Effects: Rash and Skin Reactions - Dermatology

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Inquiry about the side effects of taking Doxycycline?


I recently visited a dermatologist for my acne, and the doctor prescribed Doxycycline, 2 capsules a day.
I have been taking it for 2 weeks now, but I've developed itchy red rashes on the inner thighs and buttocks.
Some of the red areas are starting to peel.
Could this be related to Doxycycline? I have never experienced this before.
If it is, what will happen if I just ignore it and continue taking the medication until my acne clears up?

115586, 20~29 year old female. Ask Date: 2019/01/12

Dr. Wu Yuxin reply Dermatology


If you experience any side effects, you should stop taking the medication immediately.

Reply Date: 2019/01/12

More Info


Doxycycline is a tetracycline antibiotic commonly prescribed for various bacterial infections, including acne. While it is generally considered safe and effective, like all medications, it can have side effects. The symptoms you are experiencing—itchy red rashes and peeling skin on the inner thighs and buttocks—could indeed be related to the use of doxycycline.

One of the known side effects of doxycycline is photosensitivity, which can lead to skin reactions when exposed to sunlight. However, the symptoms you describe do not necessarily align with typical photosensitivity reactions. Instead, they may indicate an allergic reaction or a skin irritation caused by the medication. It is also possible that doxycycline could disrupt the normal balance of bacteria on your skin, leading to rashes or other dermatological issues.

In your case, the appearance of itchy red rashes followed by peeling skin after two weeks of doxycycline use suggests that your body may not be responding well to the medication. While some skin reactions can be mild and resolve on their own, others can be more serious and require medical attention. It is essential to consider the following points:
1. Stop the Medication: If you suspect that doxycycline is causing these skin reactions, it is crucial to stop taking the medication and consult your healthcare provider immediately. Continuing to take the medication despite experiencing side effects can lead to worsening symptoms or more severe reactions.

2. Consult a Dermatologist: Since you are already seeing a dermatologist for acne treatment, inform them about the side effects you are experiencing. They may recommend alternative treatments or medications that are less likely to cause skin reactions.

3. Monitor Symptoms: Keep an eye on the severity of your symptoms. If the rash worsens, becomes painful, or if you develop additional symptoms such as swelling, difficulty breathing, or fever, seek emergency medical attention.

4. Alternative Treatments: There are various other treatments available for acne that may not have the same side effects as doxycycline. Topical treatments, hormonal therapies, or other classes of antibiotics may be options worth discussing with your dermatologist.

5. Avoid Self-Medicating: While it may be tempting to "tough it out" until your acne clears up, it is not advisable to ignore significant side effects. Your health and well-being should always come first.

In conclusion, while doxycycline is an effective treatment for acne, it can cause side effects, including skin reactions. The symptoms you are experiencing could be related to the medication, and it is essential to address them promptly with your healthcare provider. They can help determine the best course of action, whether that means discontinuing doxycycline or switching to a different treatment plan. Always prioritize your health and communicate openly with your healthcare team about any concerns you may have.

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