Prostate Inflammation: Tamsulosin and Rowapraxin Concerns - Urology

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Hello, I would like to inquire about prostatitis?


Hello, I recently went to the hospital due to difficulty urinating and a feeling of incomplete bladder emptying.
I found out that my prostate is inflamed again.
The doctor prescribed several medications, including Tamsulosin D 0.2 mg and Rowapraxin 10 mg tablets.
I checked the contraindications for Rowapraxin, and one of them is "patients with urinary retention due to prostate enlargement." On the other hand, Tamsulosin D is indicated for "urinary obstruction associated with benign prostatic hyperplasia (BPH)" and "can relax the smooth muscles of the prostate and bladder neck." Based on this information, it seems that there might be a conflict between the two medications.
If I have difficulty urinating and a feeling of incomplete bladder emptying while taking Rowapraxin, could this negatively affect the efficacy of Tamsulosin?
Additionally, I would like to ask about the proper way to take Tamsulosin D.
Is it better to dissolve it in my mouth and swallow it with saliva, or should I swallow the whole tablet with water to ensure its effectiveness?

Niming, 20~29 year old female. Ask Date: 2019/02/27

Dr. Du Shixi reply Urology


Hello: Rowapraxin acts on the bladder, while tamsulosin primarily targets the prostate.
They are often used in combination.
Tamsulosin can be taken with water or allowed to dissolve in the mouth, and there should be no difference in effectiveness.
Wishing you good health.

Reply Date: 2019/02/27

More Info


When it comes to the treatment of prostate inflammation, particularly in the context of medications like Tamsulosin and Rowapraxin, it is essential to understand how these drugs interact and their respective roles in managing symptoms.

Tamsulosin is an alpha-1 adrenergic antagonist primarily used to treat benign prostatic hyperplasia (BPH), which is characterized by an enlarged prostate that can lead to urinary difficulties. This medication works by relaxing the smooth muscles in the prostate and bladder neck, thereby improving urine flow and reducing symptoms such as difficulty urinating and the sensation of incomplete bladder emptying.
On the other hand, Rowapraxin, which contains the active ingredient prucalopride, is primarily used to treat chronic constipation and is not typically indicated for urinary issues. The concern you raised about Rowapraxin having a contraindication for patients with urinary retention due to prostate enlargement is valid. This is because Rowapraxin can potentially exacerbate urinary retention, which is counterproductive for someone already experiencing urinary difficulties due to prostate inflammation.

The interaction between these two medications can indeed raise concerns. If Rowapraxin is taken while experiencing urinary retention or difficulty, it may counteract the beneficial effects of Tamsulosin. Tamsulosin is intended to alleviate urinary symptoms, while Rowapraxin could potentially worsen them by affecting bladder function. Therefore, it is crucial to discuss this with your healthcare provider to ensure that the treatment plan is safe and effective for your specific condition.

Regarding the administration of Tamsulosin D, it is important to follow the prescribed method for taking the medication. Tamsulosin D is often available as an orally disintegrating tablet, which means it is designed to dissolve in the mouth and can be swallowed without water. This method is generally effective and does not significantly impact the drug's efficacy. However, if you prefer or find it more comfortable to swallow the tablet whole with water, that is also acceptable. The key is to take it consistently in the same manner to maintain stable drug levels in your system.

In summary, while Tamsulosin is effective for managing urinary symptoms related to prostate inflammation, caution should be exercised when considering the use of Rowapraxin, especially if urinary retention is a concern. Always consult with your healthcare provider to clarify any potential drug interactions and to ensure that your treatment regimen is tailored to your specific needs. Additionally, follow the prescribed method for taking Tamsulosin to ensure optimal effectiveness. If you have further questions or concerns about your medications, do not hesitate to reach out to your healthcare provider for personalized advice.

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