Urinalysis Results: Glucose, BUN, and Kidney Health Concerns - Urology

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Urinalysis issues?


Hello Doctor, I recently received my health check report and found that my glucose level was 4+, and my serum urea nitrogen was 7 (slightly low).
The report indicated that these two abnormalities generally do not have an impact.
Since both my fasting blood glucose and hemoglobin A1c levels are normal, it was suggested to monitor the situation and return for a follow-up in three months.
Over the past 2-3 years, I have had tests that showed urine protein, urine ketones, and urine occult blood (all normal this year), and each time the tests were conducted 1-2 days before or after my menstrual period, including this year.
Additionally, I have been taking medication for gastroesophageal reflux disease for three months (the treatment course requires four months).
I am wondering if this could also affect the urine test results.
Furthermore, my father has type 2 diabetes, and as far as I know, there is a hereditary risk.
Should I monitor the situation and return for a urine test to rule out any potential kidney-related diseases? Thank you for your assistance!

Niming, 20~29 year old female. Ask Date: 2019/05/09

Dr. Cai Zhuorong reply Urology


The presence of glucose in urine is related to blood glucose levels and the renal threshold for glucose reabsorption.
A small number of individuals have a benign condition known as "familial renal glycosuria," where glucose can appear in the urine even in the absence of hyperglycemia.
It is recommended that you follow up with a metabolic specialist.

Reply Date: 2019/05/09

More Info


Understanding urinalysis results is crucial for assessing kidney health and identifying potential metabolic disorders such as diabetes. In your case, the presence of glucose in your urine (4+) alongside a low blood urea nitrogen (BUN) level raises some important considerations.

Firstly, glucose in the urine, known as glucosuria, typically indicates that blood glucose levels have exceeded the renal threshold for glucose reabsorption, which is usually around 180 mg/dL. However, you mentioned that your fasting blood glucose and hemoglobin A1c levels are normal, which suggests that your blood sugar levels may not be consistently elevated. This discrepancy could be due to transient factors, such as stress, illness, or even the timing of your urine test relative to your menstrual cycle, which can affect kidney function and urine composition.

Moreover, the medications you are taking for gastroesophageal reflux disease (GERD) could potentially influence your kidney function and the results of your urinalysis. Some medications can alter urine pH or affect renal tubular function, leading to changes in the excretion of substances like glucose and protein. It is essential to discuss these medications with your healthcare provider to determine if they could be contributing to your urinalysis findings.

Regarding your family history of type 2 diabetes, it is wise to be vigilant about your health, as genetics can play a significant role in the development of metabolic disorders. Regular monitoring of your blood glucose levels and kidney function is advisable, especially since you have had previous instances of protein, ketones, and occult blood in your urine. While these results were normal this year, the history of abnormal findings warrants continued observation.

The presence of glucose in your urine, even with normal blood glucose levels, should not be dismissed. It may be beneficial to repeat the urinalysis after a few months, particularly if you notice any changes in your health or if you experience symptoms such as increased thirst, frequent urination, or fatigue. Additionally, consider discussing with your doctor the possibility of conducting further tests, such as a 24-hour urine collection or a more detailed metabolic panel, to assess your kidney function and glucose metabolism more comprehensively.

In summary, while your current urinalysis results may not indicate immediate concern, they do warrant careful monitoring and follow-up. It is essential to maintain open communication with your healthcare provider, especially given your family history of diabetes and your previous abnormal urine tests. Regular check-ups and lifestyle modifications, including a balanced diet and regular exercise, can help mitigate the risk of developing diabetes and its associated complications.

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