Urethral Growths: Are They HPV-Related Warts? - Urology

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Urethral papillae


Hello Dr.
Du: Three months ago, during my health check-up, I also underwent an HPV DNA test, which detected Low risk: Type 81 (++++) .
Three weeks ago, I tested again and still found Type 81.
I checked online and found that Type 81 is also considered a type that may lead to the development of warts.
I examined the urethral opening very carefully and noticed some small growths on the left side of the urethral opening (third image) https://imgur.com/a/UMXWCZ3.
Although these growths are quite subtle and have not increased in size or number, I would like to ask if this could be warts? Is there a need for treatment? Thank you very much.

Kuo, 30~39 year old female. Ask Date: 2019/06/14

Dr. Du Shixi reply Urology


Hello: Our facility requires a personal examination for diagnosis, so it's difficult to provide a definitive answer.
Wishing you good health.

Reply Date: 2019/06/14

More Info


When it comes to understanding urethral growths and their potential relation to HPV, it’s essential to consider several factors, including the type of HPV involved, the characteristics of the growths, and the overall clinical context.

Firstly, HPV (Human Papillomavirus) is a group of more than 100 different viruses, some of which are classified as low-risk and others as high-risk. Low-risk types, such as HPV 6 and 11, are primarily associated with benign conditions like genital warts (also known as condylomata acuminata or "cauliflower-like" growths). HPV 81, which you mentioned, is also considered a low-risk type and has been associated with the development of genital warts, although it is less common than HPV 6 and 11.

The small growths you observed at the urethral opening could potentially be warts, especially given your positive HPV 81 test. However, it is important to note that not all growths in the genital area are HPV-related. Other conditions, such as skin tags, pearly penile papules, or even benign cysts, can also present as small growths. The fact that these growths are small, not increasing in size, and not causing any discomfort is a positive sign, but it does not completely rule out the possibility of them being HPV-related warts.

In terms of management, if these growths are indeed warts, treatment options include topical therapies, cryotherapy, or surgical removal, depending on their size, number, and your personal preferences. However, if they are not causing any symptoms or concerns, some healthcare providers may recommend a watchful waiting approach, especially if they are not changing over time.

It’s also crucial to consider the implications of HPV infection on your sexual health. While low-risk HPV types are generally not associated with cancer, they can still be transmitted to sexual partners. Therefore, discussing your HPV status with your partner and considering safe sex practices, such as the use of condoms, can help reduce the risk of transmission.

Regarding your concern about whether these growths need to be treated, it ultimately depends on your comfort level and the advice of your healthcare provider. If you are uncertain or anxious about the growths, it would be prudent to schedule an appointment with a healthcare professional who can perform a thorough examination and possibly a biopsy if necessary. This can provide clarity on the nature of the growths and guide appropriate management.

In conclusion, while HPV 81 can be associated with the development of genital warts, not all urethral growths are necessarily HPV-related. A careful evaluation by a healthcare provider is essential to determine the nature of the growths and the best course of action. Regular follow-ups and monitoring of your HPV status, along with vaccination against HPV if you haven't already, can also be beneficial in managing your sexual health and reducing the risk of future complications.

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