Side Effects of Gastrointestinal Medications: A Patient's Concern - Gastroenterology and Hepatology

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Side effects of gastrointestinal medications?


Hello, Doctor.
I started taking the stomach medication Lansoprazole Capsules 30mg once daily and Emetrol Tablets 10mg three times daily from May 6th.
My last menstrual period was on May 8th, and I usually have a regular cycle.
However, this month, my period started on June 3rd and has continued with some spotting until today, the 16th.
This has never happened to me before.
Additionally, I have suddenly experienced lactation.
Could this be related to taking Emetrol? I noticed that the side effects include menstrual irregularities and there is a warning about galactorrhea.
Could my symptoms be related to the stomach medication? Should I stop taking it? I originally consulted a doctor at Taipei Medical University, but they are currently abroad.
Can I bring my gastroesophageal reflux report to National Taiwan University Hospital to see a gastroenterologist there?

Wenwen, 40~49 year old female. Ask Date: 2019/06/16

Dr. Chen Shidian reply Gastroenterology and Hepatology


In a small number of patients, Metoclopramide may affect menstruation.
It is advisable to discontinue the medication and monitor the situation, or to schedule an earlier follow-up to discuss alternative medications.
If necessary, a gynecological evaluation should be considered.
In Taiwan, there are no restrictions on which hospital can be visited under the National Health Insurance, and I have no objections.

Reply Date: 2019/06/16

More Info


Hello! Thank you for your question regarding the side effects of gastrointestinal medications, specifically Lansoprazole and Emetrol, and their potential impact on your menstrual cycle and breast discharge.

First, let's discuss the medications you are taking. Lansoprazole is a proton pump inhibitor (PPI) commonly used to treat conditions like gastroesophageal reflux disease (GERD) and peptic ulcers by reducing stomach acid production. Emetrol, on the other hand, is an over-the-counter medication used to relieve nausea and upset stomach, often associated with motion sickness or gastrointestinal disturbances.

Regarding your concerns about menstrual irregularities and the unexpected discharge from your breasts, it is important to note that while both medications have their own side effects, the symptoms you are experiencing may not be directly linked to them.
1. Menstrual Irregularities: While Lansoprazole is not typically associated with menstrual changes, some studies suggest that PPIs can affect hormone levels indirectly by altering the gut microbiome or through other mechanisms. However, this is not a common side effect. Emetrol, primarily used for nausea, does not have a well-documented link to menstrual irregularities. Stress, changes in diet, or other medications can also contribute to changes in your menstrual cycle. If your menstrual cycle has been regular and you are now experiencing prolonged bleeding, it is advisable to consult with a healthcare provider to rule out other potential causes, such as hormonal imbalances or other underlying conditions.

2. Galactorrhea (Breast Discharge): The presence of milk-like discharge from the breasts, known as galactorrhea, can be caused by several factors, including hormonal changes, medications, or even stress. While Emetrol does not typically cause galactorrhea, some medications can increase prolactin levels, leading to this symptom. It is crucial to discuss this with your doctor, as they may want to evaluate your hormone levels and consider whether any other medications or health conditions could be contributing to this issue.

Given your symptoms, it may be prudent to temporarily stop taking Emetrol and consult with your healthcare provider. They can assess whether your symptoms are indeed related to the medications or if further investigation is needed.
As for your question about switching to another hospital for further evaluation, it is generally acceptable to bring your medical records, including reports related to your gastroesophageal reflux disease, to another healthcare provider. This can help ensure continuity of care and allow the new physician to understand your medical history and treatment plan.

In summary, while your current medications may not be the direct cause of your menstrual irregularities or breast discharge, it is essential to consult with a healthcare provider for a thorough evaluation. They can help determine the underlying cause of your symptoms and whether any changes to your medication regimen are necessary. Always prioritize open communication with your healthcare team regarding any new or concerning symptoms you experience while on medication.

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