Does Amoxicillin Affect the Effectiveness of Birth Control Pills? - Obstetrics and Gynecology

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Amoxicillin and oral contraceptives?


I am currently taking the oral contraceptive pill, Yuzpe, and I am on the third pill of a new pack.
I have caught a cold, and my doctor has prescribed me cold medication along with amoxicillin.
I know that amoxicillin is an antibiotic, and I would like to know how significantly it will affect the efficacy of the oral contraceptive pill.
Will it cause the contraceptive pill to become ineffective? Should I use additional contraceptive measures during the course of taking the medication and for one week after stopping it?

Shirley, 20~29 year old female. Ask Date: 2019/06/17

Dr. Huang Jianzhong reply Obstetrics and Gynecology


I am currently taking the contraceptive pill Yu Yue and am on the third pill of a new pack.
I have caught a cold, and my doctor prescribed me cold medication along with amoxicillin.
I know that amoxicillin is an antibiotic, and I would like to know how significantly it affects the contraceptive pill and whether it could render the contraceptive ineffective.

Answer: The impact on the contraceptive pill is minimal, and it will not render the contraceptive ineffective.
Is it necessary to use additional safety measures during the medication period and for a week after stopping the medication?
Answer: No, it is not necessary.

Reply Date: 2019/06/17

More Info


Amoxicillin is a commonly prescribed antibiotic that is often used to treat various bacterial infections. One of the concerns that many women have when taking antibiotics, particularly in conjunction with birth control pills, is whether the antibiotic will affect the effectiveness of their contraceptive method.
The general consensus among healthcare professionals is that most antibiotics, including Amoxicillin, do not significantly interfere with the effectiveness of hormonal contraceptives such as birth control pills. The primary concern regarding antibiotics and birth control arises from the antibiotic rifampin, which is known to reduce the effectiveness of hormonal contraceptives by increasing the metabolism of hormones in the liver. However, Amoxicillin does not have this effect and is not associated with a decrease in contraceptive efficacy.

In your case, since you are taking the birth control pill "优悦" (Yuyue) and have just started a new pack, taking Amoxicillin for your cold should not compromise the effectiveness of your birth control. It is important to continue taking your birth control pills as directed, and you should not need to use additional contraceptive methods while taking Amoxicillin.

Regarding the use of cold medications, it is essential to be cautious, as some over-the-counter cold medications can contain ingredients that may interact with hormonal contraceptives. However, if your doctor prescribed the cold medication, they would have considered any potential interactions. Always inform your healthcare provider about all medications you are taking, including over-the-counter drugs, to ensure there are no adverse interactions.

If you are still concerned about the effectiveness of your birth control during this time, it is reasonable to use a backup method, such as condoms, until you feel more confident about the situation. This is especially true if you are taking any other medications that may have interactions or if you have any gastrointestinal issues (like vomiting or diarrhea) that could affect the absorption of your birth control pills.

In summary, Amoxicillin is not expected to affect the effectiveness of your birth control pills. However, if you have any lingering concerns or if your situation changes, it is always best to consult with your healthcare provider for personalized advice. They can provide you with the most accurate information based on your specific health needs and circumstances.

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