Can Antibiotics Affect Gonorrhea Test Results After Exposure? - Urology

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Can gonorrhea still be detected after taking antibiotics?


Hello doctor, I had sexual intercourse with a stranger three days ago.
I experienced a sore throat and went to see an ENT specialist.
Two days later, I had burning pain while urinating at night and felt like I couldn't fully empty my bladder, along with lower abdominal pain, so I went to see a urologist the next day.
The urologist performed a urine culture and said it would take a week for the results.
My urination has been normal, and when I checked the report, he said there were no bacteria.
I would like to ask if the cephradine antibiotic prescribed by the ENT could affect the results of a gonorrhea test? I am currently experiencing a severe headache, swollen eyes, and still have phlegm in my throat, and I'm worried it might be gonococcal pharyngitis.

Lin Mu Mu, 20~29 year old female. Ask Date: 2019/07/08

Dr. Du Shixi reply Urology


Hello: Medication can affect test results.
If you still have symptoms, you should seek medical attention and inform the doctor that you had sexual intercourse with a stranger a few days ago, so the doctor can take it into consideration.
Wishing you good health.

Reply Date: 2019/07/08

More Info


Antibiotics, including cephradine, can potentially affect the results of tests for gonorrhea, but the extent of this impact can vary based on several factors. In your case, you mentioned that you had unprotected sexual contact and subsequently developed symptoms that led you to seek medical attention. You were prescribed cephradine for your throat pain, and now you are concerned about whether this antibiotic could interfere with the gonorrhea test results.

First, it's important to understand how gonorrhea testing works. The most common tests for gonorrhea involve either a urine sample or a swab from the affected area (such as the throat or urethra). These tests look for the presence of Neisseria gonorrhoeae, the bacteria that causes gonorrhea. If you were tested after starting antibiotics, there is a possibility that the antibiotic could suppress the bacteria, leading to a false-negative result. This means that the test might not detect the infection even if it is present.

Cephradine is a type of cephalosporin antibiotic, which is effective against a variety of bacterial infections. While it is generally effective against many strains of bacteria, including some that cause respiratory infections, it may not be as effective against Neisseria gonorrhoeae. However, if the antibiotic was taken shortly before the test, it could potentially reduce the bacterial load enough to affect the test results.

In your situation, since you started taking cephradine after your exposure and before your gonorrhea test, it is advisable to consider the timing of your antibiotic use in relation to the test. If the test was conducted shortly after starting the antibiotic, there is a chance that it could have influenced the results. If you are still experiencing symptoms such as throat pain, eye discomfort, and abdominal pain, it is crucial to follow up with your healthcare provider. They may recommend a repeat test or a different type of test that is less likely to be affected by antibiotics, such as a nucleic acid amplification test (NAAT), which is more sensitive and specific for detecting gonorrhea.

Additionally, it is essential to communicate openly with your healthcare provider about your symptoms and concerns. They can provide guidance on the best course of action, which may include further testing or treatment options. If you suspect that you may have gonorrhea or any other sexually transmitted infection (STI), it is important to refrain from sexual activity until you have been evaluated and treated appropriately to prevent transmission to others.

In summary, while antibiotics like cephradine can potentially affect gonorrhea test results, the impact depends on various factors, including the timing of the test and the specific bacteria involved. If you have concerns about your test results or ongoing symptoms, it is best to consult with your healthcare provider for further evaluation and management.

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