Elevated Fetal Protein and Mild Fatty Liver in Health Checkups - Family Medicine

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Health check issues


Hello Doctor, I would like to ask if a slight increase in fetal protein within the normal range has any significance.
An ultrasound examination showed mild fatty liver, and there is no hepatitis B or C.
However, prior to the health check, I had a severe cold with a high fever for many days and took cold medication for about ten days.
The test results indicated mild fatty liver, and the fetal protein level is 3 (compared to 1 last year).
I also have a history of mental health issues (I am seeing a psychiatrist).
Some doctors mentioned that cold medications typically do not affect fetal protein levels, but if there is mild liver inflammation or fatty liver due to the cold or medication, it could potentially alter the fetal protein levels.
However, if the levels are within the standard range and not significantly elevated, it should be acceptable, correct? Thank you.

Xiao Xiong, 30~39 year old female. Ask Date: 2019/07/11

Dr. Xiao Yongxun reply Family Medicine


Dear Miss Bear: AFP (Alpha-Fetoprotein) is translated into Chinese as 甲種胎兒蛋白.
It is a specific glycoprotein synthesized by hepatocytes during embryonic development, which promotes rapid proliferation of fetal liver tissue, resulting in high levels in fetal blood.
However, its concentration gradually decreases within approximately 1 to 4 weeks after birth.
The normal range for adults is 0 to 25 µg/L (which may vary depending on the laboratory).
Clinically, it is primarily used as a tumor marker reference in the treatment of hepatocellular carcinoma.
Additionally, various conditions such as hepatitis, cirrhosis, embryonal tumors, certain gastrointestinal malignancies, congenital biliary atresia, tyrosinemia, some metastatic liver cancers, benign liver tumors, and embryonal tumors (such as testicular teratomas and ovarian cancer) may also lead to varying degrees of AFP elevation.
An AFP level of 3 µg/L is still within the normal range; theoretically, it should not be a concern.
Your physician is correct in stating, "If it does not exceed the standard or significantly increase, it is acceptable." If you still have questions or concerns, it is advisable to consult a hepatobiliary and gastroenterology specialist for regular follow-up.

Reply Date: 2019/07/11

More Info


Elevated fetal protein levels and mild fatty liver can indeed raise concerns during health checkups, but understanding their implications requires a nuanced approach.
Firstly, let's discuss the fetal protein, commonly referred to as alpha-fetoprotein (AFP). AFP is a protein that is typically produced by the fetal liver, but it can also be present in adults, particularly in certain medical conditions. In adults, elevated AFP levels can indicate liver disease, including hepatitis, cirrhosis, and liver cancer, but slight elevations may not always signify a serious issue. Your reported level of 3, compared to last year's 1, is indeed a slight increase, but it is crucial to consider the context. If this level remains within the normal range, it may not be clinically significant. However, it is essential to monitor it over time, especially if you have other risk factors for liver disease.

Regarding your mild fatty liver diagnosis, this condition, also known as hepatic steatosis, is characterized by an accumulation of fat in liver cells. It is often associated with obesity, diabetes, and excessive alcohol consumption, but it can also occur in individuals who are otherwise healthy. Since you mentioned a recent weight gain of 10 kilograms, this could be a contributing factor to your fatty liver. Additionally, the recent severe illness and the medications you took may have transiently affected your liver function, leading to mild inflammation and, consequently, a slight increase in AFP levels.
It is important to note that while mild fatty liver is often benign, it can progress to more severe liver conditions if not managed properly. Therefore, lifestyle modifications are crucial. This includes adopting a balanced diet low in saturated fats and sugars, increasing physical activity, and maintaining a healthy weight. Regular follow-ups with your healthcare provider are also essential to monitor liver function and any changes in AFP levels.

In your case, since you have a history of mental health issues and were on medication, it is wise to discuss with your healthcare provider whether any of your medications could potentially impact liver function. While most common cold medications are not known to significantly affect liver enzymes or AFP levels, individual responses can vary, and it is always best to consult your doctor.

In summary, while a slight increase in AFP and a diagnosis of mild fatty liver warrant attention, they do not necessarily indicate a severe problem, especially if other liver function tests are normal. Continuous monitoring, lifestyle changes, and open communication with your healthcare provider will be key in managing your liver health. If you have any further concerns or if your AFP levels continue to rise, additional tests may be warranted to rule out any underlying conditions.

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