Do Antibiotics Affect Birth Control Pills? Drug Interactions - Obstetrics and Gynecology

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Drug interactions


Hello, I have been taking the oral contraceptive pill (Yasmin) for 5 months.
Before starting the 6th pack, I caught a cold and took cold medication for 9 days, which included antibiotics.
Will this affect the contraceptive effectiveness? The medications are: COMBICILLIN CAPSULES 10mg, AMSOL TABLETS 30mg, DIPROPHYLLIN TABLETS, MEQAZINE TABLETS 5mg.
Thank you for taking the time to respond.

Ni Ke, 30~39 year old female. Ask Date: 2019/10/05

Dr. Huang Jianzhong reply Obstetrics and Gynecology


I have been taking the oral contraceptive pill (Yaz) for 5 months.
Before starting the 6th pack, I caught a cold and took cold medication for 9 days, which included antibiotics.
Will this affect the contraceptive effectiveness?
Answer: Generally, it should not affect the contraceptive effectiveness.
The medications taken include: COMBICILLIN CAPSULES, TNYH TABLETS 10mg, AMSOL TABLETS 30mg, DIPROPHYLLIN TABLETS, MEQAZINE TABLETS 5mg.

Reply Date: 2019/10/05

More Info


When it comes to the interaction between antibiotics and birth control pills, there is a common concern among women regarding the effectiveness of their contraceptive methods while taking antibiotics. The short answer is that most antibiotics do not significantly affect the efficacy of hormonal contraceptives, including birth control pills. However, there are exceptions, and understanding these interactions is crucial for ensuring effective contraception.

The primary concern arises from the fact that some antibiotics can potentially interfere with the metabolism of contraceptive hormones in the liver. The most notable antibiotic that has been shown to have this effect is rifampin, which is used to treat tuberculosis and some other infections. Rifampin can induce liver enzymes that metabolize estrogen and progestin, the hormones found in most birth control pills, leading to decreased effectiveness of the contraceptive method. However, the antibiotics you mentioned—COMBICILLIN, TNYH TABLES, AMSOL TABLES, DIPROPHYLLIN TABLES, and MEQAZINE TABLES—are not known to have this effect.

In general, the majority of antibiotics, including penicillins and cephalosporins, do not have a clinically significant impact on the effectiveness of birth control pills. Therefore, if you are taking common antibiotics for a respiratory infection or other minor ailments, you can usually continue to rely on your birth control method without concern.

However, it is essential to consider a few factors. First, if you experience gastrointestinal side effects from antibiotics, such as vomiting or diarrhea, this could potentially affect the absorption of the birth control pill. If you vomit within two hours of taking your pill or have severe diarrhea, it is advisable to use a backup contraceptive method, such as condoms, until you can ensure that your birth control pill is effective again.

Second, if you are taking any other medications alongside your antibiotics, it is crucial to consult with your healthcare provider or pharmacist about potential interactions. Some medications can affect the metabolism of contraceptive hormones, leading to reduced effectiveness.

Lastly, it is always a good practice to communicate with your healthcare provider about any concerns regarding medications and their interactions with birth control. If you are uncertain about the specific antibiotics you are taking and their potential effects on your contraceptive method, do not hesitate to ask your doctor or pharmacist for clarification.

In summary, while most antibiotics do not affect the efficacy of birth control pills, it is essential to be aware of specific medications that may interact and to monitor for any gastrointestinal side effects that could impact absorption. If you have any doubts or experience any unusual symptoms, consulting with your healthcare provider is the best course of action to ensure your contraceptive method remains effective.

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