Do Antibiotics Affect Birth Control Pills? Drug Interactions - Obstetrics and Gynecology

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Drug interactions / Antibiotics and oral contraceptives?


Hello Doctor: I am currently on my third month of taking oral contraceptives, and I have taken the 15th pill of this pack today.
However, I need to take antibiotics (Amoxicillin) for three consecutive days due to a dental visit.
Will this affect the efficacy of my birth control pills?

Ms. T, 20~29 year old female. Ask Date: 2020/09/08

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, it generally does not have an impact.
Wishing you good health.

Reply Date: 2020/09/08

More Info


When it comes to the interaction between antibiotics and birth control pills, the concern primarily revolves around whether antibiotics can diminish the effectiveness of hormonal contraceptives. In your case, you are currently taking a birth control pill and have been prescribed amoxicillin for a dental issue.
The general consensus among healthcare professionals is that most antibiotics do not significantly affect the efficacy of birth control pills. The most notable exception is rifampin, an antibiotic used to treat tuberculosis, which has been shown to decrease the effectiveness of hormonal contraceptives. However, amoxicillin, which is a penicillin-type antibiotic, does not have this effect.
The mechanism by which some antibiotics might theoretically interfere with birth control pills involves the alteration of gut flora and the potential for reduced reabsorption of estrogen. However, studies have shown that this effect is minimal and not clinically significant for most antibiotics, including amoxicillin. Therefore, while it is always prudent to be cautious and consult with your healthcare provider, the likelihood that amoxicillin will compromise your birth control pill's effectiveness is low.

It's important to note that while the risk of reduced efficacy is minimal, other factors can influence the effectiveness of birth control pills, such as missed doses, gastrointestinal issues (like vomiting or diarrhea), or interactions with other medications. Therefore, if you are taking your birth control pill consistently and correctly, the addition of amoxicillin should not pose a significant risk to its effectiveness.

If you have any concerns about potential interactions or if you experience any unusual symptoms while taking both medications, it is advisable to reach out to your healthcare provider for personalized advice. They can provide guidance based on your specific health situation and any other medications you may be taking.

In summary, while it is always wise to be aware of potential drug interactions, you can generally feel reassured that taking amoxicillin while on birth control pills should not compromise their effectiveness. However, maintaining open communication with your healthcare provider is key to ensuring your contraceptive method remains reliable.

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Hello, it generally does not have an impact. Wishing you good health.

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