Elevated Immature White Blood Cells and Atypical Lymphocytes: What to Know - Oncology

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Blood test shows elevated levels of immature white blood cells and atypical lymphocytes?


I previously went to the hospital due to unstable blood pressure.
The doctor initially planned to check my cholesterol levels through a blood test, but instead found immature white blood cells and atypical lymphocytes at 10%.
The internist recommended a referral to a hematology-oncology specialist.
What could this indicate? Given that my referral appointment is at the end of October, should I urgently seek care at another hospital?

Miss Lin, 40~49 year old female. Ask Date: 2019/10/15

Dr. Hu Ziren reply Oncology


If immature white blood cells contain blast cells, it may indicate a hematologic malignancy, and it is advisable to seek medical attention promptly.

Reply Date: 2019/10/15

More Info


Elevated immature white blood cells and atypical lymphocytes can be concerning findings in a blood test, as they may indicate an underlying hematological issue. Immature white blood cells, also known as blasts, are typically not present in significant numbers in healthy individuals. Their presence can suggest a range of conditions, from benign reactive processes to more serious conditions such as leukemia or other hematological malignancies. Atypical lymphocytes, on the other hand, can indicate a response to infection, inflammation, or malignancy.

In your case, the discovery of these abnormal cells during a routine check for cholesterol is significant. The recommendation to see a hematologist or an oncologist suggests that the physician is taking these findings seriously. It is essential to understand that while not all cases of elevated immature white blood cells and atypical lymphocytes indicate cancer, they warrant further investigation to rule out serious conditions.

The hematologist will likely perform additional tests, including a complete blood count (CBC) with differential, bone marrow biopsy, flow cytometry, and possibly cytogenetic studies. These tests will help determine the nature of the abnormal cells and whether they are indicative of a malignancy such as acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), or other disorders like lymphoproliferative disorders.

Given that you have been advised to see a specialist, it is crucial to follow through with that appointment. However, if you are experiencing symptoms such as unexplained fever, night sweats, significant weight loss, or persistent fatigue, it may be prudent to seek immediate medical attention. These symptoms can be associated with more severe conditions and should not be ignored.

In the meantime, it is advisable to maintain a healthy lifestyle, including a balanced diet, regular exercise, and adequate hydration. Avoiding stress and ensuring proper sleep can also support your overall health during this uncertain time.

If you feel that your symptoms are worsening or if you are experiencing new symptoms, do not hesitate to seek care sooner than your scheduled appointment. It is always better to err on the side of caution when it comes to your health.

In summary, elevated immature white blood cells and atypical lymphocytes are significant findings that require further evaluation by a hematologist. While waiting for your appointment, monitor your symptoms closely and seek immediate care if necessary. Your health and well-being are paramount, and timely intervention can make a significant difference in outcomes.

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