PCOS Diagnosis: Questions About Hormones and Treatment - Obstetrics and Gynecology

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Polycystic Ovary Syndrome (PCOS) Diagnosis Issues


Recently, I went to the gynecology department for a check-up due to weight gain (I went from 65 kg to 70 kg over six months, and I am 166 cm tall).
The doctor performed an abdominal ultrasound and said that my uterus was normal (I'm not sure if the doctor checked my ovaries).
I had blood tests done, and during my follow-up visit, my LH was 9.15 and FSH was 2.85.
The doctor diagnosed me with polycystic ovary syndrome (PCOS) and prescribed Clomid and Primolut-Nor, but my menstrual cycle and flow are both normal (30-35 days), and I do not have symptoms of hirsutism.
I feel that my case is not typical for PCOS, so I would like to ask the doctor:
1.
Is it possible that there are other endocrine disorders causing hormonal abnormalities and obesity? Should I see a metabolic specialist for further evaluation?
2.
If I start taking the medication, will it affect the tests conducted by the metabolic specialist?
3.
Can an abdominal ultrasound detect ovarian issues, or is a transvaginal ultrasound necessary?
(Thank you, Dr.
Huang.
I have a lot of questions.
The doctor I initially consulted only looked at the blood test results and prescribed medication without giving me a chance to clarify my many doubts.)

Zeng, 20~29 year old female. Ask Date: 2019/11/04

Dr. Huang Yiwen reply Obstetrics and Gynecology


Hello Ms.
Tseng: Typical polycystic ovary syndrome (PCOS) is often associated with long-term menstrual irregularities, hirsutism, and obesity.
The diagnosis requires evidence of at least menstrual irregularities and elevated male hormones.
An ultrasound examination can provide further confirmation.
Relying solely on an LH/FSH ratio greater than 3 and a body mass index (BMI) slightly above 25 (your BMI is calculated as 70/1.66*1.66) to diagnose polycystic ovarian syndrome would be too tenuous.

1.
If you are concerned, you can visit a metabolic medicine or family medicine clinic for further evaluation.

2.
It is advisable not to take medication, as your menstrual cycle is normal, and there is no need for ovulation induction drugs (such as Clomid) or progesterone (such as Primolut-Nor).

3.
As long as you are not significantly overweight and do not have bladder distension, a standard abdominal ultrasound should be able to visualize the ovaries; however, a transvaginal ultrasound will provide clearer images.

Reply Date: 2019/11/04

More Info


Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder that affects many women of reproductive age. It is characterized by a combination of symptoms and hormonal imbalances, which can include irregular menstrual cycles, elevated levels of androgens (male hormones), and the presence of multiple cysts on the ovaries. Your concerns regarding the diagnosis and treatment of PCOS are valid, especially given your recent experiences with weight gain and hormonal testing.

1. Other Endocrine Disorders: It is indeed possible that other endocrine disorders could be contributing to your hormonal imbalances and weight gain. Conditions such as thyroid disorders (hypothyroidism or hyperthyroidism), adrenal gland disorders (like Cushing's syndrome), or even insulin resistance can mimic or exacerbate the symptoms of PCOS. If your menstrual cycles are regular and you do not exhibit typical symptoms of PCOS, such as hirsutism (excessive hair growth) or significant weight gain, it may be worthwhile to consult with an endocrinologist or a metabolic specialist. They can conduct further tests to rule out other conditions that might be affecting your hormonal balance and overall health.

2. Impact of Medications on Testing: Starting medications like Clomid (clomiphene citrate) and Primolut-Nor (a progestin) may influence your hormonal levels and could potentially affect the results of subsequent tests. Clomid is often prescribed to induce ovulation, while Primolut-Nor is used to regulate menstrual cycles. If you are considering seeing a metabolic specialist, it would be advisable to discuss the timing of your medication use with them. They may recommend waiting a certain period after stopping the medications before conducting tests to get a clearer picture of your hormonal status.

3. Ultrasound for Ovarian Assessment: Regarding your question about ultrasound, both abdominal and transvaginal (internal) ultrasounds can be used to assess the ovaries. However, transvaginal ultrasound is generally more effective for visualizing the ovaries and detecting the presence of cysts. It provides a clearer view and can help in the assessment of ovarian morphology, which is crucial for diagnosing PCOS. If you have concerns about whether your ovaries were adequately assessed during your abdominal ultrasound, you might want to discuss this with your healthcare provider and consider a transvaginal ultrasound for a more thorough evaluation.

In summary, while your current diagnosis of PCOS is based on hormonal testing and ultrasound findings, it is essential to consider the broader context of your health. Regular menstrual cycles and the absence of typical symptoms may warrant further investigation into other potential endocrine disorders. Consulting with a specialist can provide you with a more comprehensive understanding of your condition and guide you in making informed decisions about your treatment options. Additionally, maintaining a healthy lifestyle, including a balanced diet and regular exercise, can significantly impact your overall well-being and may help manage symptoms associated with PCOS.

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