Elevated GPT Levels: Should You See a Family Doctor? - Gastroenterology and Hepatology

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Abnormal findings in health check report GPT?


Hello Doctor, I recently received my employee health check report for October, which shows a GPT level of 38 (the report states normal range: 10-35).
Five years ago, my GPT level was 21.
I found that the normal range for GPT is below 40.
Should I follow up with a family physician? Additionally, I received a measles vaccination in September due to my work at the hospital; could this have any impact? I do not smoke or drink alcohol, and I do not have hepatitis B.
I usually go to bed late and get about 5-6 hours of sleep.
Thank you for your assistance.

VV, 30~39 year old female. Ask Date: 2019/12/05

Dr. Chen Shidian reply Gastroenterology and Hepatology


Follow up in three months.
If overweight or diagnosed with fatty liver, prioritize weight loss.

Reply Date: 2019/12/05

More Info


Elevated levels of GPT (Glutamate Pyruvate Transaminase), also known as ALT (Alanine Aminotransferase), can be a cause for concern, especially when they exceed the normal range. In your case, a GPT level of 38, while slightly elevated above the normal range of 10-35, does warrant some attention, particularly since it is a notable increase from your previous level of 21 five years ago.
First, it’s important to understand what GPT/ALT levels indicate. This enzyme is primarily found in the liver, and elevated levels can suggest liver inflammation or damage. Common causes of elevated ALT levels include fatty liver disease, hepatitis, certain medications, and lifestyle factors such as obesity, alcohol consumption, and sedentary behavior. However, since you mentioned that you do not smoke or drink alcohol and have no history of hepatitis B or C, it is essential to consider other factors that might contribute to this elevation.

Regarding your recent measles vaccination, it is unlikely that this would have a significant impact on your ALT levels. Vaccinations can cause transient changes in liver enzymes, but these are typically mild and resolve quickly. However, if you have any concerns about the timing of your vaccination and the elevation in your liver enzymes, it is worth discussing with your healthcare provider.

Given your lifestyle habits, such as late sleep and limited sleep duration (5-6 hours), it may be beneficial to evaluate how these factors could be affecting your overall health, including liver function. Chronic sleep deprivation can lead to various health issues, including metabolic syndrome, which can contribute to liver problems.

Now, should you see a family doctor? Yes, it would be advisable to follow up with a family doctor or a primary care physician. They can provide a comprehensive evaluation of your health, including a review of your medical history, lifestyle factors, and any symptoms you may be experiencing. They may recommend further testing, such as additional liver function tests, imaging studies like an ultrasound, or even a referral to a specialist if necessary.

In your case, monitoring your liver enzymes over time is crucial. Your family doctor may suggest repeating the ALT test in a few months to see if the levels normalize or continue to rise. They can also help you implement lifestyle changes that may improve your liver health, such as dietary modifications, increasing physical activity, and improving sleep hygiene.

In summary, while your GPT level of 38 is only slightly elevated, it is essential to take it seriously, especially given the increase from your previous level. Consulting with a family doctor will provide you with the guidance and support needed to address this issue effectively. They can help you understand the implications of your test results, monitor your liver health, and ensure that any potential underlying conditions are identified and managed appropriately. Taking proactive steps now can help prevent more significant health issues in the future.

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