Mild Yellowing of the Eyes: Is It a Sign of Liver Issues? - Gastroenterology and Hepatology

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Slightly yellow sclera?


Hello doctor, I recently had blood tests and my liver enzyme levels were at 150.
The urine test showed normal bilirubin levels, but a few days later, I noticed that the whites of my eyes were slightly yellow, although not very noticeable.
Could this be related to the elevated liver enzyme levels?

Niming, 20~29 year old female. Ask Date: 2020/02/05

Dr. Chen Shidian reply Gastroenterology and Hepatology


It is possible; please return for a follow-up appointment to check the bilirubin levels.

Reply Date: 2020/02/05

More Info


The mild yellowing of the eyes, known as scleral icterus or jaundice, can indeed be a sign of underlying liver issues, but it is essential to consider the context of your overall health and any accompanying symptoms. In your case, you mentioned that your liver function tests showed elevated levels, specifically an AST of 150, which is significantly higher than the normal range. This elevation can indicate liver inflammation or damage, but it does not automatically mean that you have a severe liver condition.

Jaundice occurs when there is an excess of bilirubin in the bloodstream. Bilirubin is a yellow compound that is produced during the normal breakdown of red blood cells. The liver typically processes bilirubin, and any dysfunction in this organ can lead to an accumulation of bilirubin, resulting in the yellowing of the skin and eyes. However, mild yellowing may not always correlate directly with liver function tests, especially if the elevation is not extreme.

In your situation, since your urine tests for bilirubin were normal, it suggests that your liver is still functioning to some extent, as bilirubin is usually excreted through urine when the liver is processing it properly. The fact that your yellowing is mild and not very pronounced is also a positive sign. It is crucial to monitor your liver function closely, especially given the elevated AST levels.
You should consider the following steps:
1. Follow-Up Testing: Regular follow-up with your healthcare provider is essential. They may recommend additional tests, such as an ultrasound of the liver or further blood tests, to assess liver function and rule out any specific liver diseases.

2. Lifestyle Modifications: If you have not already, consider making lifestyle changes that support liver health. This includes maintaining a balanced diet, avoiding alcohol, staying hydrated, and engaging in regular physical activity.

3. Monitor Symptoms: Keep an eye on any additional symptoms that may arise, such as fatigue, abdominal pain, changes in stool color, or further yellowing of the skin and eyes. If you notice any worsening symptoms, seek medical attention promptly.

4. Family History Consideration: Given your family history of liver issues, it may be beneficial to discuss this with your healthcare provider. They may recommend genetic testing or screening for specific liver conditions that could be hereditary.

5. Consult a Specialist: If your primary care physician is concerned about your liver function, they may refer you to a hepatologist, a specialist in liver diseases, for further evaluation and management.

In conclusion, while mild yellowing of the eyes can be associated with liver issues, it is essential to interpret this symptom in conjunction with your liver function tests and overall health. Regular monitoring and proactive management are key to ensuring that any potential liver issues are addressed promptly. Always consult with your healthcare provider for personalized advice and treatment options based on your specific situation.

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