Concerns About Urinary Issues After Switching Diabetes Medications - Urology

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Questions regarding the use of diabetes medications that promote glucose excretion?


Hello, Dr.
Du:
I have type 2 diabetes and have been taking the extended-release metformin prescribed by my endocrinologist for many years.
Earlier this year, my doctor recommended switching to empagliflozin.
Since starting this medication, I have noticed that my toilet bowl becomes very moldy after urination.
If I don't clean the area where urine drips or the toilet itself, it will mold within a day.
Even if I clean it every time, it still molds every two to three days.
Additionally, I have noticed a change in the odor of my urine, which has become stronger.
When I use the restroom or take a shower, my underwear and genital area also have a noticeable smell.
I am unsure if I should see a urologist.

I understand that this medication causes glucose to be excreted through urine, but I would like to know if this is a normal phenomenon.
It feels like pouring a sugary drink into the toilet without flushing or spilling it on myself.
The medication's information leaflet mentions that it may cause urinary tract infections and genital yeast infections.
What symptoms should I look for that would warrant a visit to a urologist? I haven't reached my follow-up appointment yet, and I'm quite worried, which is why I'm reaching out.
Thank you, doctor!

Yeh, 30~39 year old female. Ask Date: 2020/02/21

Dr. Du Shixi reply Urology


Hello: I am not a medication specialist, but this drug has a good effect on controlling blood sugar levels.
As you mentioned, there are risks of urinary tract infections, genital fungal infections, and skin infections.
If you notice cloudy urine or experience urinary pain, it is important to maintain cleanliness and dryness in the genital area, as moisture can lead to skin infections, redness, and swelling.
In such cases, you should seek medical attention.
You can refer to the side effects section of the drug's package insert for more information.
Wishing you good health.
You can also look up the drug's package insert online for reference.

Reply Date: 2020/02/21

More Info


It sounds like you're experiencing some concerning symptoms after switching your diabetes medication to Emglitinide (恩美糖膜衣錠). Let's break down your situation and address your concerns regarding urinary issues, medication side effects, and when to seek further medical attention.

Firstly, Emglitinide is a medication that helps control blood sugar levels by stimulating insulin secretion from the pancreas. One of the side effects of this medication, as you mentioned, is that it can lead to increased glucose excretion in the urine. This can potentially create a more favorable environment for yeast and bacteria, which might explain the increased frequency of mold growth in your toilet and the changes in urine odor. The presence of glucose in the urine can indeed lead to a sweet smell, similar to that of sugary drinks, which might be what you are experiencing.

Regarding the mold growth in your toilet, this is not uncommon for individuals with diabetes, especially if blood sugar levels are not well controlled. High glucose levels in the urine can promote the growth of bacteria and fungi, leading to unpleasant odors and potential infections. It is essential to maintain good hygiene practices, including regular cleaning of the toilet and ensuring that any spills are promptly cleaned up to reduce the risk of mold and bacteria proliferation.

As for the changes in urine odor and the increased frequency of urination, these can be signs of a urinary tract infection (UTI), especially if accompanied by other symptoms such as burning during urination, increased urgency, or any unusual discharge. Given that Emglitinide can increase the risk of UTIs and yeast infections, it is advisable to monitor your symptoms closely. If you notice any signs of infection, such as fever, chills, or persistent discomfort, you should seek medical attention promptly.

In terms of when to see a urologist, you should consider doing so if you experience any of the following:
1. Persistent changes in urine color or odor that do not resolve.

2. Pain or burning sensation during urination.

3. Increased urgency or frequency of urination that disrupts your daily life.

4. Any signs of infection, such as fever or chills.

5. Unexplained changes in your urinary habits that concern you.

It is also important to communicate with your primary care physician or endocrinologist about the side effects you are experiencing from Emglitinide. They may want to adjust your medication or explore alternative treatments that may have fewer side effects. Managing diabetes effectively is crucial, and your healthcare provider can help you find the best approach tailored to your needs.

In summary, while some changes in urinary habits can be expected with the use of certain diabetes medications, it is essential to remain vigilant for signs of infection or other complications. Maintaining good hygiene, monitoring your symptoms, and communicating with your healthcare provider will help ensure that you manage your diabetes effectively while minimizing any adverse effects from your medications. If in doubt, do not hesitate to seek medical advice, as early intervention can prevent more serious complications.

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