GERD and Side Effects of Dexilant 60mg: Your Concerns Addressed - Gastroenterology and Hepatology

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Taking medication for gastroesophageal reflux disease (GERD) (Dexilant 60mg) may cause issues with gastric obstruction?


I was recently diagnosed with gastroesophageal reflux disease (GERD) and a mild ulcer (0.3 cm), so my doctor prescribed me Dexilant (dexlansoprazole) 60 mg.
However, since I started taking the medication, I often experience stomach discomfort after 4 to 6 hours of fasting, which becomes more severe when I wake up in the morning.
The discomfort subsides after I eat.
Could this be a side effect of the medication, or is there another issue with my stomach?

Xiao Wei, 30~39 year old female. Ask Date: 2020/03/11

Dr. Lin Minghui reply Gastroenterology and Hepatology


Hello: This type of medication is a proton pump inhibitor used to treat acid-related disorders such as gastroesophageal reflux disease (GERD) and peptic ulcers.
It is important to be aware of any potential allergies to the medication.
Common gastrointestinal side effects of this class of drugs include diarrhea, while abdominal pain, nausea, and bloating are less common.
If you experience gastric discomfort that improves after eating, it may still be related to gastritis or excessive gastric acid secretion.
In addition to medication, it is advisable to pay attention to dietary habits, such as reducing the intake of caffeine, sweets, and spicy foods.
You may also refer to the medication's package insert for any related side effects.
Wishing you peace and health! Sincerely, Dr.
Ming-Hui Lin, Attending Physician, Gastroenterology Department, Taoyuan General Hospital, Ministry of Health and Welfare.

Reply Date: 2020/03/11

More Info


Dexilant (dexlansoprazole) is a proton pump inhibitor (PPI) commonly prescribed for the treatment of gastroesophageal reflux disease (GERD) and related conditions, such as gastric ulcers. It works by reducing the amount of stomach acid produced, which helps alleviate symptoms associated with acid reflux and promotes healing of the esophagus and stomach lining.

Your experience of having stomach discomfort or "gastric pain" after taking Dexilant, especially when you are on an empty stomach, raises some important considerations. While Dexilant is generally well-tolerated, it can have side effects, and individual responses to medication can vary significantly.
Common side effects of Dexilant may include:
1. Gastrointestinal Issues: Some patients report experiencing nausea, vomiting, diarrhea, or abdominal pain. These symptoms can sometimes occur as the body adjusts to the medication or due to changes in stomach acid levels.

2. Headaches: Some individuals may experience headaches as a side effect of PPIs.

3. Dizziness: Although less common, dizziness can occur in some patients.

4. Nutritional Absorption: Long-term use of PPIs can affect the absorption of certain nutrients, such as magnesium, calcium, and vitamin B12, potentially leading to deficiencies.

5. Rebound Acid Hypersecretion: After discontinuation of PPIs, some patients may experience an increase in stomach acid production, leading to symptoms of acid reflux returning or worsening.

Given your symptoms of gastric discomfort that worsen when fasting, it is possible that the medication is affecting your gastric motility or the way your stomach processes food. It is also important to consider that your underlying condition (GERD and the presence of a gastric ulcer) may contribute to these sensations, particularly if the ulcer is causing irritation or if the reflux is not adequately controlled.

Here are a few recommendations:
- Timing of Medication: Dexilant is typically taken once daily, and it is often recommended to take it at least 30 minutes before a meal. If you are taking it at a different time, consider discussing this with your healthcare provider.

- Dietary Adjustments: Pay attention to your diet. Certain foods can exacerbate GERD symptoms, such as spicy foods, caffeine, chocolate, and fatty foods. Keeping a food diary may help identify triggers.

- Consult Your Doctor: Since you are experiencing significant discomfort, it is crucial to discuss these symptoms with your healthcare provider. They may want to evaluate whether the Dexilant is the right medication for you or if an adjustment in dosage or a different medication might be necessary.
- Further Evaluation: If the discomfort persists, further evaluation may be warranted to rule out other gastrointestinal issues, such as gastritis or complications related to the ulcer.

In summary, while Dexilant is effective for managing GERD and ulcers, it can cause side effects that may mimic or exacerbate underlying gastrointestinal issues. Open communication with your healthcare provider is essential to ensure that your treatment plan is effective and to address any side effects you may be experiencing.

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