Duodenal Ulcers: Treatment, Side Effects, and Recovery - Gastroenterology and Hepatology

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Hello, Doctor.
After undergoing an upper gastrointestinal endoscopy, the physician mentioned that I have some erosion (likely referring to a duodenal ulcer) and mild gastritis.
The doctor prescribed Sucralfate (20 mg), Magnesium Oxide tablets (250 mg), and Gaskin (40 mg), and I have been taking the medication for nearly 20 days.
My questions are as follows:
1.
Initially, when I started taking the medication, I experienced frequent diarrhea, followed by a feeling of needing to go again but often unable to, accompanied by some cramping pain.
I often woke up at 5 AM with abdominal pain (and also experienced borborygmi), after which I would go to the bathroom.
Since the side effects of the three medications mentioned include diarrhea (and also constipation and abdominal pain), I wonder if the diarrhea, constipation, and abdominal pain are related to the medication.
However, in the past week, I have not had diarrhea and mainly have soft stools (the Magnesium Oxide acts as an antacid and stool softener), and my abdominal pain has decreased, although I still experience some constipation.
Could this be due to better tolerance of the medication, leading to reduced side effects? Is this phenomenon normal? Would I need to undergo further colonoscopy?
2.
Are Sucralfate and Magnesium Oxide tablets (antacid and stool softener) different in their actions? Don’t they both have antacid effects? Wouldn’t that be redundant? I am concerned about taking too many medications and overloading my system.
Is it possible to stop taking Magnesium Oxide and Gaskin? If I do not have bloating, can I skip Gaskin? Can I just take Sucralfate alone?
3.
I generally take my medication on time (though I did stop for 5 days twice and switched to another medication for 5 days), but after a few good days, I experience a recurrence lasting about 1 to 2 days (symptoms include gastric discomfort, acid reflux, nausea, loss of appetite, fatigue, and a sensation of a foreign body in my throat).
What could be the reason for this? How long should I take medication for the ulcer to heal? Is complete recovery possible in the future?
4.
How effective is Sucralfate? Although I am not experiencing diarrhea now, I feel more nauseous and have a poorer appetite compared to before.
Should the doctor adjust the three medications prescribed? Taking Magnesium Oxide and Gaskin three times a day, is this beneficial for the body in the long term? Will it not be too burdensome, especially since Magnesium Oxide contains magnesium? I switched to another medication for 5 days; how effective is that medication?
5.
I often feel a sensation of a foreign body in my throat.
Is this due to gastroesophageal reflux, stomach acid, or taking too many medications? Does it require special treatment? Thank you, Doctor, for your answers; I appreciate your help.

A Ying, 40~49 year old female. Ask Date: 2020/03/30

Dr. Cai Anshun reply Gastroenterology and Hepatology


Hello: 1.
First, discontinue the medication to see if the side effects persist.
2.
One medication suppresses gastric acid secretion, while the other neutralizes gastric acid; their mechanisms of action are different.
3.
Depending on clinical needs, improvement does not necessarily require continuous medication use.
4.
Generally, gastrointestinal medications have few side effects, and short-term use is not harmful.
5.
A sensation of a foreign body in the throat is also one of the symptoms of gastroesophageal reflux.
If you have any questions, you may consult an otolaryngologist.
=> When medication for gastroesophageal reflux is ineffective, lifestyle and dietary habits should be improved.
Changhua Hospital cares about your health.
Dr.
Tsai An-Shun.

Reply Date: 2020/03/30

More Info


Understanding duodenal ulcers and their treatment is crucial for managing symptoms and promoting recovery. Based on your situation, let's address your questions systematically.

1. Side Effects of Medication: The medications you are taking—瘍寧 (likely a proton pump inhibitor), 氧化鎂錠 (magnesium oxide), and 加斯克兒錠 (possibly an antacid)—can indeed cause gastrointestinal side effects. Diarrhea, constipation, and abdominal pain are common side effects associated with these medications. Initially, your body may react strongly to the introduction of these drugs, leading to symptoms like diarrhea and abdominal cramping. However, as your body adjusts to the medication, these symptoms may diminish, which seems to be the case for you now. It’s not uncommon for patients to experience fluctuations in bowel habits when starting new medications. If your symptoms persist or worsen, or if you experience significant discomfort, further evaluation, such as a colonoscopy, may be warranted to rule out other underlying conditions.

2. Differences Between Medications: 瘍寧 (the proton pump inhibitor) and 氧化鎂錠 (magnesium oxide) serve different purposes. The proton pump inhibitor reduces stomach acid production, promoting healing of the ulcer, while magnesium oxide acts as an antacid and can also help soften stools. They do not have overlapping effects, so taking both can be beneficial. However, if you are not experiencing symptoms like bloating or discomfort, you may discuss with your doctor the possibility of reducing or eliminating the magnesium oxide, especially if you feel it is unnecessary. Always consult your healthcare provider before making changes to your medication regimen.

3. Duration of Treatment and Recurrence: The treatment duration for duodenal ulcers can vary, but it typically lasts for 4 to 8 weeks, depending on the severity of the ulcer and the response to treatment. It is essential to adhere to the prescribed treatment plan to promote healing. Recurrence of symptoms after stopping medication can occur, especially if the underlying causes (such as H. pylori infection or NSAID use) are not addressed. Long-term management may be necessary for some patients, and lifestyle modifications, such as dietary changes and stress management, can also play a role in preventing recurrence.

4. Efficacy of 瘍寧: 瘍寧 is generally effective for treating ulcers, but side effects like nausea and decreased appetite can occur. If you are experiencing these symptoms, it’s important to communicate this with your doctor. They may consider adjusting your medication or dosage to improve your comfort. Long-term use of magnesium oxide and antacids can be safe for many patients, but monitoring is essential to avoid potential side effects, especially with magnesium levels.

5. Sensation of a Lump in the Throat: The feeling of a lump in your throat could be related to gastroesophageal reflux disease (GERD), which is common in patients with ulcers. This sensation can also be exacerbated by anxiety or the side effects of medications. If this sensation persists, it may be worth discussing with your healthcare provider, who may recommend further evaluation or treatment options.

In summary, managing a duodenal ulcer involves a combination of medication, lifestyle changes, and regular follow-up with your healthcare provider. It’s essential to communicate any side effects or concerns you have about your treatment to ensure that your regimen is effective and comfortable. Always consult your physician before making any changes to your medication or treatment plan.

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