Steroid Treatment Shrinks Lymphoma: What You Need to Know - Oncology

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Steroids can reduce the size of lymphoma?


Hello Dr.
Chen, I would like to ask you about a case where a suspected brain lymphoma was investigated, and a lumbar puncture revealed a significant number of lymphocytes.
Due to brain swelling and dizziness, corticosteroids were administered for decompression, which resulted in a reduction of the tumor size.
However, the biopsy pathology report could not confirm whether it was lymphoma, so treatment could not be initiated.
The doctor advised to have another MRI in three months.
After returning home, I have been experiencing night sweats, fever, fatigue, and weakness.

1.
If these symptoms persist, should I seek medical attention immediately?
2.
I am very concerned… If it is lymphoma and the report is unclear, could delaying treatment lead to a negative outcome? I would appreciate your analysis.

Xiao Yuan, 30~39 year old female. Ask Date: 2020/03/30

Dr. Chen Sirong reply Oncology


Xiao Yuan / 36 years old / Female
1.
If the symptoms persist, should I seek medical attention first?
A: Yes.
2.
I'm very worried...
If it's lymphoma, will the unclear report delay treatment?
A: If a 3D stereotactic biopsy is performed to remove a brain tumor, can you accept it? Confirmation is necessary before treatment.
Not confirming may delay treatment.
As a patient, reflecting on this later (the hindsight perspective) is what it means.
Taoyuan Hospital, Dr.
Chen Si-Rong.

Reply Date: 2020/03/30

More Info


Steroid treatment for lymphoma can be a complex and nuanced topic, especially in the context of your situation. It’s important to understand both the benefits and potential risks associated with steroid use in the management of lymphoma, as well as the implications of your symptoms and the need for further medical evaluation.


Understanding Steroid Treatment in Lymphoma
Steroids, such as prednisone or dexamethasone, are often used in the treatment of lymphoma for several reasons. They can help reduce inflammation, alleviate symptoms, and, in some cases, shrink tumors. In your case, the use of steroids was initiated to manage brain swelling and associated symptoms like dizziness. The fact that the tumor size decreased following steroid treatment is not uncommon, as steroids can induce a temporary reduction in tumor volume due to their anti-inflammatory effects. However, this does not necessarily indicate a cure or definitive treatment for lymphoma.


Symptoms and Their Implications
The symptoms you are experiencing—night sweats, fever, fatigue, and weakness—are often associated with lymphoma and can indicate disease activity. These symptoms can also be related to other conditions, including infections or inflammatory processes. Given that you have undergone a lumbar puncture and have lymphocytes present, it is crucial to monitor these symptoms closely.

1. Should You Seek Medical Attention?
Yes, if your symptoms persist or worsen, it is advisable to seek medical attention. Persistent night sweats, fever, and fatigue could indicate that the underlying condition is not stable and may require further evaluation. Your healthcare provider may want to perform additional tests, such as blood work or imaging studies, to assess your current condition and determine if there is a need for more aggressive treatment.

2. Concerns About Delayed Treatment
It is understandable to be concerned about the potential for delayed treatment if lymphoma is indeed present. The ambiguity in your pathology report can be frustrating, but it is essential to follow your physician's recommendations regarding follow-up imaging and evaluations. The three-month wait for a follow-up MRI is standard in many cases, as it allows for a clearer picture of how the condition is evolving. In the meantime, maintaining open communication with your healthcare team about any changes in your symptoms is critical.


Next Steps
- Follow-Up Appointments: Ensure you keep your scheduled follow-up appointments and communicate any new or worsening symptoms to your healthcare provider.

- Symptom Management: Discuss with your doctor about managing your current symptoms, which may include supportive care measures or adjustments in your steroid regimen.

- Further Testing: If your symptoms persist, your doctor may consider additional diagnostic tests to clarify the diagnosis and guide treatment decisions.


Conclusion
In summary, while steroid treatment can provide symptomatic relief and shrink lymphomas temporarily, it is not a definitive treatment. The presence of concerning symptoms warrants further evaluation and possibly a more proactive approach to diagnosis and treatment. It is crucial to work closely with your healthcare team to ensure that any potential lymphoma is appropriately managed and that you receive the care you need during this uncertain time. Always prioritize your health and do not hesitate to seek medical advice when you have concerns about your symptoms.

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