Unresolved Urethral Discomfort: Seeking Answers and Diagnosis - Urology

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Persistent urethral discomfort remains undiagnosed?


Hello, doctor! I am the one who asked about the undiagnosed condition of Xiao Gao this morning.
Over the past year and a half, I have tested for HIV and syphilis twice, both results were negative after the window period.
I would like to ask: 1) About 12 days after the incident, I visited a urologist and underwent a urine test without any medication.
Since it was during the initial phase, I wonder why there were no results...
The doctor told me that they were testing for the DNA of bacteria (such as gonorrhea and chlamydia).
Isn't DNA testing usually quite accurate? Additionally, what other blood tests can be performed? 2) What symptoms are associated with chronic prostatitis? What diagnostic methods are available to confirm it? If treatment is required, how long does it typically take? 3) Initially, I only experienced severe itching in the anterior urethra without any other symptoms, but about six months ago, I started experiencing significant pain in the posterior urethra.
Doesn't this resemble urethritis? Thank you, doctor!

Xiao Gao, 30~39 year old female. Ask Date: 2020/04/13

Dr. Du Shixi reply Urology


Hello: 1) Urine tests primarily for syphilis and HIV.
2) Chronic prostatitis is difficult to diagnose, prone to recurrence, and treatment may take at least several months.
You can refer to http://www.shutien.org.tw/dr_doc_detail.aspx?bookid=603.
Since your tests are normal, it may not necessarily be the case.
Additionally, due to the poor response to medication, other issues should be considered.
Wishing you good health.

Reply Date: 2020/04/13

More Info


Dear Patient,
Thank you for reaching out with your concerns regarding unresolved urethral discomfort. I understand that this has been a challenging situation for you, and I will do my best to provide clarity on your questions.

1. Testing for STIs: It’s good to hear that you have tested negative for HIV and syphilis multiple times. When it comes to testing for sexually transmitted infections (STIs) such as gonorrhea and chlamydia, nucleic acid amplification tests (NAATs) are indeed highly sensitive and specific. However, there are a few reasons why your initial tests may not have yielded results. First, the timing of the test is crucial; while you mentioned that you were tested around 12 days post-exposure, some infections may not be detectable until a few weeks after exposure. Additionally, if you were asymptomatic at the time of testing, the likelihood of detecting an infection may decrease. If you have persistent symptoms, it may be worthwhile to repeat the tests or consider additional tests for other STIs that may not have been included in your initial screening. Blood tests can also check for other infections, including herpes simplex virus (HSV) and hepatitis, which may not be routinely included in standard STI panels.

2. Chronic Prostatitis Symptoms and Diagnosis: Chronic prostatitis can manifest with a variety of symptoms, including pelvic pain, discomfort during urination, painful ejaculation, and sometimes flu-like symptoms. The diagnosis can be challenging, as symptoms can overlap with other conditions. To confirm chronic prostatitis, a healthcare provider may perform a digital rectal exam (DRE) to assess the prostate and may also recommend tests such as a urinalysis, prostate-specific antigen (PSA) test, or even a prostate massage to analyze prostatic secretions for signs of infection or inflammation. Treatment duration can vary widely depending on the underlying cause, but it often involves antibiotics if a bacterial infection is suspected, along with anti-inflammatory medications and lifestyle changes.

3. Urethral Symptoms: The progression of your symptoms from itching to significant pain in the urethra is concerning and may suggest an underlying condition that requires further evaluation. While urethritis (inflammation of the urethra) is a common cause of such symptoms, other conditions such as prostatitis, interstitial cystitis, or even pelvic floor dysfunction could also be contributing factors. It’s important to have a thorough evaluation by a urologist, who may recommend imaging studies or cystoscopy (a procedure to look inside the bladder and urethra) to rule out structural abnormalities or other underlying issues.

In summary, I recommend following up with your urologist to discuss your ongoing symptoms and the possibility of further testing. It’s crucial to communicate all your symptoms clearly, as this will help guide the diagnostic process. If you have not already, consider asking about a referral to a specialist in chronic pelvic pain or a urologist with experience in treating chronic prostatitis and related conditions.

I hope this information helps you navigate your situation, and I wish you the best in finding relief and answers.

Sincerely,
Doctor Q&A Teams


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