Recurrence vs. New Infection of Genital Warts: Key Insights - Surgery

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Cauliflower recurrence


Hello, doctor.
I would like to ask a question.
About ten years ago, I was diagnosed with genital warts and underwent treatment.
I continued to follow up at the clinic every three months.
I also have regular Pap smears and pelvic exams every year, and there have been no recurrences during these ten years.
I had a pelvic exam and Pap smear last November, and everything was fine! However, I was recently diagnosed with genital warts again.
Could this be a recurrence? Isn’t it considered cured if there hasn’t been a recurrence for two years? Or could this be a new infection? What should I pay more attention to in this situation? Thank you!

Y, 30~39 year old female. Ask Date: 2020/05/21

Dr. Ke Fangxu reply Surgery


Recurrence or new infections may depend on whether there is a history of exposure.
Although it is said that if warts do not recur for two years after treatment, one can be considered cured, this does not mean that they will never recur in a lifetime.
If new lesions appear, treatment will be necessary again, and it is important to practice protected sexual intercourse.

Reply Date: 2020/05/21

More Info


Genital warts, caused by certain strains of the human papillomavirus (HPV), can indeed present a complex scenario when it comes to understanding recurrence versus new infections. Your situation raises important questions about the nature of HPV infections and the implications for your health.

Firstly, it is essential to clarify that HPV can remain dormant in the body for years after the initial infection. This means that even if you have not shown any symptoms or had visible warts for a long time, the virus could still be present in your system. When the immune system is compromised or under stress, the virus may reactivate, leading to the recurrence of warts. However, in your case, since you have been symptom-free for ten years and have had regular check-ups, it is also possible that the recent diagnosis of genital warts could be a new infection rather than a recurrence.

The distinction between recurrence and new infection is significant. A recurrence implies that the same strain of HPV that caused your initial warts has reactivated, while a new infection suggests exposure to a different strain of HPV. Given that there are over 100 types of HPV, some of which are associated with genital warts, it is entirely plausible to contract a new strain even after being treated for another.

Regarding your question about being considered "cured" after two years without symptoms, it is important to note that while the absence of visible warts and negative Pap smear results are encouraging, they do not guarantee that the virus is entirely gone. HPV can remain in a latent state, and the risk of reactivation or new infection persists, especially if exposed to new partners who may carry different strains of the virus.

In terms of monitoring and management, it is crucial to maintain regular follow-ups with your healthcare provider. They can offer guidance on the best practices for managing HPV, including potential vaccination against other strains of the virus that may cause genital warts or cervical cancer. The HPV vaccine is effective in preventing infections from the most common high-risk and low-risk strains, and it is recommended for individuals up to age 26, and in some cases, up to age 45.

Additionally, practicing safe sex, including the use of condoms, can help reduce the risk of transmitting or acquiring new strains of HPV. While condoms do not provide complete protection against HPV, they can significantly lower the risk of transmission.

In summary, your recent diagnosis of genital warts could either indicate a recurrence of the previous infection or a new infection from a different strain of HPV. Regular monitoring and preventive measures are essential in managing your health moving forward. If you have any concerns or questions about your diagnosis or treatment options, do not hesitate to discuss them with your healthcare provider. They can provide personalized advice based on your medical history and current health status.

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