Do Topical Antibiotics Affect Birth Control Pill Effectiveness? - Obstetrics and Gynecology

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Will topical antibiotics affect the efficacy of oral contraceptives?


I have been taking the oral contraceptive pill, Yaz, for a month.
Today is the sixth day of my menstrual cycle, and I had unprotected intercourse, but I no longer have menstrual bleeding.
My menstrual cycle is typically about 26-28 days.
I just remembered that I have been applying erythromycin ointment and a skin ointment for an ear piercing infection, approximately once a day, and there is about a two-hour gap between applying these ointments and taking my contraceptive pill.
Today, I also applied an ointment for angular cheilitis due to a sore in my mouth (I apologize, I do not have the ingredients of the medications on hand).
Will this affect the effectiveness of the oral contraceptive pill? Do I still need to take emergency contraception? Thank you!

Tang Tang, 20~29 year old female. Ask Date: 2020/05/28

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, it generally does not have an impact.
Wishing you good health.

Reply Date: 2020/05/28

More Info


When it comes to the effectiveness of birth control pills, many women often wonder about the potential interactions with various medications, including topical antibiotics. In your case, you've been using topical ointments like erythromycin and a skin cream while on the birth control pill, and you're concerned about whether these could affect the pill's effectiveness.

Firstly, it's important to understand how birth control pills work. They primarily prevent ovulation, thicken cervical mucus to block sperm, and thin the uterine lining to prevent implantation. Most commonly prescribed oral contraceptives are highly effective when taken correctly, with a failure rate of less than 1% when used perfectly.

Topical antibiotics, such as erythromycin, are generally not known to interfere with the effectiveness of hormonal contraceptives. The primary concern with antibiotics and birth control pills arises with systemic antibiotics, which are taken orally or injected and can affect the liver's metabolism of hormones. However, topical antibiotics are applied directly to the skin and do not enter the bloodstream in significant amounts, thus they are unlikely to impact the efficacy of your birth control pills.

As for the other topical medications you mentioned, such as the ointment for angular cheilitis (the mouth sore), unless they contain ingredients that are known to interact with hormonal contraceptives, they should not affect the pill's effectiveness either. Since you mentioned that you applied these medications with a two-hour interval from taking your birth control pill, this timing further reduces any potential risk of interaction.

Regarding your menstrual cycle, it's worth noting that some women experience changes in their periods when they start taking birth control pills. This can include lighter periods or even missed periods, especially in the initial months of use. If you are on the pill and have been consistent with your intake, the likelihood of pregnancy is low, even if you had unprotected intercourse during your menstrual cycle.

In conclusion, based on the information provided, the topical antibiotics and creams you have been using should not affect the effectiveness of your birth control pill. Therefore, you likely do not need to take emergency contraception (the "morning-after pill") unless you missed a dose of your birth control pill or have other concerns about potential contraceptive failure.

However, if you continue to have concerns about your birth control method or experience any unusual symptoms, it is always best to consult with your healthcare provider. They can provide personalized advice based on your medical history and current medications. Remember, maintaining open communication with your healthcare provider about all medications you are taking, including topical treatments, is crucial for your reproductive health.

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Hello, it generally does not have an impact. Wishing you good health.

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