Myasthenia Gravis
Hello, doctor.
Recently, I have been experiencing double vision and hand tremors.
I first went to an ophthalmologist, who said my eyes were fine and recommended that I see a neurologist.
After several follow-up visits, the neurologist diagnosed me with myasthenia gravis and prescribed a two-month supply of medication, advising me to return for a follow-up in two months.
I would like to ask: Is this condition lifelong? Besides diarrhea, what other side effects can occur from taking Mestinon? Should I have a blood test to check for acetylcholine receptor antibodies (I have only undergone electromyography, chest X-ray, and chest CT)? Additionally, how can I address the hand tremors? They are causing some inconvenience since I work in a chemistry lab (the doctor mentioned that taking medication for tremors could lead to erectile dysfunction, so he advised against it).
Lastly, after being diagnosed with this condition, will I still be able to exercise (like jogging or playing basketball)?
Mr. Li, 20~29 year old female. Ask Date: 2020/06/05
Dr. Jiang Junyi reply Neurology
Hello: You mentioned that this disease is lifelong? A: It may be necessary to identify the underlying causes and other diagnoses.
If it is a thymoma, surgery may effectively control the disease.
What are the side effects of frequently taking Pyridostigmine besides diarrhea? A: The side effects of Pyridostigmine include blurred vision, dry mouth, abdominal cramps, and diarrhea, which are due to excess acetylcholine and the effects on the parasympathetic nervous system.
Should I get a blood test to check for acetylcholine receptor antibodies (I have only done electromyography, chest X-ray, and chest CT)? A: The presence of acetylcholine receptor antibodies (AchR antibodies) in serum is the most specific test for diagnosing myasthenia gravis.
The positive rate of serum antibodies among patients with generalized myasthenia gravis is 75% to 85%, while it is only about 50% in ocular myasthenia gravis.
Patients with negative serum antibodies can be referred to a medical center for further antibody testing.
How can I address my hand tremors? They slightly interfere with my work in chemical experiments (the doctor said that taking medication for tremors could lead to erectile dysfunction, so I was advised against it).
A: The side effects of beta-blockers like propranolol include bradycardia, dizziness, fatigue or weakness, diarrhea, and gastrointestinal discomfort.
You can start with a low dose, such as 5 mg twice a day; the impact on sexual function should be minimal.
Can I still exercise (jogging, playing basketball, etc.) after being diagnosed with this condition? A: Symptoms of myasthenia gravis may worsen due to increased body temperature, pregnancy, menstrual cycles, medications affecting neuromuscular transmission, or concurrent hyperthyroidism or hypothyroidism.
Exercise should not have a significant impact.
It is recommended that you consult a neurologist for discussion and treatment.
Shin Kong Hospital and other institutions are authorities in the research and diagnosis of myasthenia gravis.
Wishing you good health, peace, and joy.
Dr.
Tao, Neurology, cares about you.
Reply Date: 2020/06/05
More Info
Myasthenia Gravis (MG) is an autoimmune neuromuscular disorder characterized by weakness and rapid fatigue of voluntary muscles. It occurs when the immune system mistakenly attacks the communication between nerves and muscles, primarily affecting the acetylcholine receptors at the neuromuscular junction. This condition can lead to various symptoms, including double vision (diplopia), muscle weakness, and in some cases, difficulty swallowing or breathing.
Is Myasthenia Gravis a Lifelong Condition?
Yes, Myasthenia Gravis is generally considered a chronic condition. However, the severity and frequency of symptoms can vary significantly among individuals. Some patients may experience periods of remission where symptoms improve or disappear, while others may have persistent symptoms. Treatment can help manage symptoms effectively, allowing many individuals to lead active lives. Regular follow-ups with a neurologist are essential to monitor the condition and adjust treatment as necessary.
Side Effects of Medications
You mentioned taking "大力丸" (which likely refers to a form of corticosteroid or immunosuppressant). Common side effects of corticosteroids include weight gain, increased appetite, mood changes, and gastrointestinal issues, including diarrhea. Long-term use can lead to more serious side effects such as osteoporosis, hypertension, and increased risk of infections. It's crucial to discuss any side effects you experience with your healthcare provider, as they may need to adjust your medication or dosage.
Testing for Acetylcholine Receptor Antibodies
Testing for acetylcholine receptor antibodies is a standard procedure in diagnosing Myasthenia Gravis. While you have already undergone electromyography (EMG) and imaging studies, checking for these antibodies can provide further confirmation of the diagnosis. It's advisable to discuss this with your neurologist, as it can help tailor your treatment plan more effectively.
Addressing Hand Tremors
Hand tremors can be particularly troublesome, especially for someone working in a precise field like chemistry. While your neurologist has advised against medication that could exacerbate erectile dysfunction, there are other strategies to manage tremors. These may include:
1. Physical Therapy: A physical therapist can provide exercises to improve muscle control and coordination.
2. Occupational Therapy: An occupational therapist can suggest adaptive tools or techniques to help you perform tasks more easily.
3. Stress Management: Stress can exacerbate tremors, so techniques such as mindfulness, yoga, or deep-breathing exercises may be beneficial.
4. Medication Review: If tremors are significantly impacting your work, discuss alternative medications with your doctor that may not have the same side effects.
Exercise and Lifestyle
Exercise is generally encouraged for individuals with Myasthenia Gravis, but it should be approached with caution. Activities like jogging and basketball can be beneficial for overall health, but it's essential to listen to your body. Here are some tips:
1. Moderation: Start with low-intensity exercises and gradually increase as tolerated.
2. Rest: Incorporate rest periods into your routine, especially if you notice increased fatigue.
3. Hydration: Stay well-hydrated, as dehydration can worsen symptoms.
4. Avoid Overexertion: Pay attention to your body’s signals. If you feel fatigued or weak, it’s important to stop and rest.
In summary, while Myasthenia Gravis is a lifelong condition, effective management through medication, lifestyle adjustments, and regular medical follow-up can significantly improve your quality of life. Always consult your healthcare provider before making any changes to your treatment or lifestyle to ensure they align with your specific health needs.
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