Cytomegalovirus Infection and Its Impact on Liver Health - Gastroenterology and Hepatology

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Hepatitis diagnosed with cytomegalovirus?


Approximately when I first entered the workforce, I experienced persistent low-grade fevers for over a month, which led to hepatitis.
During that time, I would easily fall asleep due to fatigue.
I recall being diagnosed with a cytomegalovirus (CMV) infection and my immune levels were found to be below the standard.
However, I cannot recall when or where I might have contracted the virus...
I have never engaged in sexual activity, nor have I had any intimate behaviors involving saliva exchange.
The only thing I can think of is that I was curious about the taste of breast milk when friends had babies and I tried a little, or I spent some time daily with a small infant.
After treatment, my liver enzyme levels returned to normal.
However, the doctor at that time mentioned that the cytomegalovirus might reactivate after ten years or so, but I can't remember the details...

Could you please explain why someone like me would contract cytomegalovirus? How often should I have follow-up examinations in the coming years? Which specialty should I consult? After treatment, with normal liver enzyme levels, is this considered fully resolved like a cold, or is it more like HIV where it never fully goes away? Are there any specific precautions I should take?

MDD, 30~39 year old female. Ask Date: 2020/06/05

Dr. Chen Shidian reply Gastroenterology and Hepatology


Currently, there are no specific preventive treatments.
Maintaining a normal daily routine, keeping up immunity, practicing good hand hygiene, and being cautious about sexual contact transmission are sufficient.

Reply Date: 2020/06/05

More Info


Cytomegalovirus (CMV) infection is a common viral infection that can have significant implications for liver health, particularly in individuals with compromised immune systems. CMV is a member of the herpesvirus family and is known for its ability to remain dormant in the body after the initial infection. This means that while many people may experience mild or no symptoms, the virus can reactivate later, especially in individuals with weakened immune systems.

In your case, it seems that you experienced an acute CMV infection that led to liver inflammation, commonly referred to as hepatitis. This can occur because the virus can directly affect liver cells or trigger an immune response that results in liver damage. The symptoms you described, such as prolonged low-grade fever and fatigue, are typical of viral infections, including CMV.

Regarding your concerns about how you contracted the virus, CMV is primarily spread through bodily fluids, including saliva, urine, blood, and breast milk. While you mentioned that you had not engaged in sexual activities or intimate exchanges, it is possible to contract CMV through casual contact, especially with infants, as they can shed the virus in their saliva and urine. Your curiosity about tasting breast milk could also be a potential route of exposure, although it is less common.

After treatment, if your liver function tests returned to normal, it indicates that the acute phase of the infection has resolved. However, CMV is known for its ability to remain latent in the body, which means that it can reactivate later, particularly if your immune system becomes compromised due to stress, illness, or other factors. This is why your doctor may have mentioned the possibility of reactivation after several years.

For monitoring your health post-infection, it is generally recommended to have regular follow-ups with a healthcare provider, particularly a specialist in infectious diseases or hepatology. The frequency of these check-ups can vary based on your overall health and any underlying conditions you may have. A yearly check-up is often sufficient for individuals who have recovered from an acute CMV infection, but your doctor may suggest more frequent monitoring if there are concerns about your immune status or liver health.

In terms of treatment, while CMV can be managed effectively, it is not entirely analogous to a common cold that you can fully "recover" from. Instead, it is more similar to other chronic viral infections, such as HIV, in that the virus can remain in the body and has the potential to reactivate. However, with a healthy immune system, many people live without significant issues related to CMV.

To maintain your health, it is essential to practice good hygiene, especially when around infants or immunocompromised individuals, as they are more susceptible to CMV. Additionally, managing stress, maintaining a balanced diet, and ensuring adequate sleep can help support your immune system.

In summary, while you have recovered from your acute CMV infection, it is crucial to remain vigilant about your health and have regular check-ups to monitor for any potential reactivation of the virus. If you experience any new symptoms or health changes, do not hesitate to consult your healthcare provider.

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