Elevated Liver Enzymes: Impact of Intense Exercise - Gastroenterology and Hepatology

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Elevated liver function tests?


Hello, Vice Dean Chen.
A few days ago, during a health check at a certain hospital, I received a phone call notifying me that my liver enzyme levels were elevated, with a value of 107.
I usually do not stay up too late, going to bed around 10 or 11 PM, so my routine is relatively normal.
However, in the days leading up to the health check, I engaged in intense exercise and played sports, which resulted in muscle soreness.
I would like to inquire whether my elevated liver enzyme levels are closely related to this significant amount of exercise.

Mr. Chen, 20~29 year old female. Ask Date: 2020/06/18

Dr. Chen Shidian reply Gastroenterology and Hepatology


Intense exercise (such as running a marathon) can indeed lead to an increase in GOT levels, while the impact on GPT is relatively minor.
The elevation in GOT levels is due to the release of this enzyme from muscle tissue and is not related to liver function.
Resting and rehydrating, followed by monitoring, is advisable.

Reply Date: 2020/06/18

More Info


Elevated liver enzymes, particularly alanine aminotransferase (ALT) and aspartate aminotransferase (AST), can often raise concerns regarding liver health. However, it is essential to understand that various factors can contribute to these elevations, including intense physical activity. In your case, the significant exercise you engaged in prior to your health check-up could indeed be a contributing factor to the elevated liver enzyme levels.

When you exercise vigorously, especially if you are not accustomed to such levels of activity, your muscles can undergo stress and damage. This can lead to the release of muscle enzymes into the bloodstream, which may be mistaken for liver enzyme elevation. The enzymes AST and ALT are not only found in the liver but also in muscle tissue. Therefore, intense exercise can cause transient increases in these enzymes, which may not necessarily indicate liver damage.

In your situation, the muscle soreness you experienced after intense workouts could be a sign of delayed onset muscle soreness (DOMS), which is common after engaging in strenuous physical activity. This condition can lead to the release of enzymes from muscle tissue into the bloodstream, potentially causing a false elevation in liver enzyme tests. It is also worth noting that other factors, such as dehydration, dietary changes, or even stress, can influence liver enzyme levels.

To further assess your liver health, it would be prudent to consider a few steps:
1. Rest and Recovery: Allow your body some time to recover from the intense exercise. This includes adequate rest and hydration, which can help normalize enzyme levels.

2. Re-testing: After a period of rest (usually a week or two), consider re-testing your liver enzymes. If the levels return to normal, it may indicate that the previous elevation was indeed related to your exercise routine.

3. Consultation with a Healthcare Provider: If the enzyme levels remain elevated or if you experience other symptoms such as jaundice (yellowing of the skin or eyes), fatigue, or abdominal pain, it is essential to consult with a healthcare provider. They may recommend additional tests, such as imaging studies or further blood tests, to rule out any underlying liver conditions.

4. Exercise Modifications: If you are new to exercising or have recently increased your activity level, it may be beneficial to gradually build up your intensity and duration. This approach can help your body adapt and reduce the risk of muscle damage and subsequent enzyme elevation.

5. Dietary Considerations: Maintaining a balanced diet that supports liver health is crucial. While protein is essential for muscle recovery, excessive protein intake, especially in individuals with pre-existing liver conditions, can lead to increased ammonia levels, which may affect liver function. However, in healthy individuals, moderate protein intake should not significantly impact liver enzyme levels.

In summary, while elevated liver enzymes can be concerning, they can also be influenced by factors such as intense exercise. Monitoring your symptoms, allowing for recovery, and consulting with a healthcare provider will help ensure that any potential liver issues are appropriately addressed. Remember, maintaining a balanced approach to exercise and nutrition is key to overall health and well-being.

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