Managing Sleep Disorders: Safe Use of Medications and Supplements - Pharmacology

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Medication Consultation


Hello, pharmacist...
I have been experiencing insomnia and autonomic nervous system disorders, and I have been seeing a psychiatrist.
The doctor prescribed me EURODIN (Ulodin) to take one and a half tablets half an hour before bedtime, and I have been taking it for four weeks.
Last week, the doctor mentioned a newer medication called IMOVANE (Zopiclone) and advised me to take half a tablet before bed.
He said that I could gradually switch between these two medications.
I would like to know if combining these two medications would result in an excessive dosage.
Additionally, the doctor prescribed another medication called SEPIRONE (Buspirone), to be taken three times a day, which is supposed to increase serotonin levels.
Recently, a friend heard about my insomnia and gifted me a dietary supplement called Happy Banana Tablets, claiming it is very effective and has no side effects.
The recommended dosage is one tablet in the morning and two tablets before bed.
However, I did some research and found that Happy Banana Tablets contain a lot of tryptophan, which can also be converted into serotonin.
If I take the dietary supplement along with the prescribed SEPIRONE, could this lead to excessive serotonin levels and potentially cause serotonin syndrome? Thank you for taking the time to respond!

KOP, 40~49 year old female. Ask Date: 2020/06/27

Dr. Chen Yuemei reply Pharmacology


Hello:
1.
Regarding the sleep aid Erodin, the onset of action is approximately 0.5 to 1.6 hours, with a duration of effect lasting up to 10 to 24 hours.
Imovane has an onset of action of about 15 to 30 minutes, with a duration of effect lasting up to 3.5 to 6.5 hours.
This means that Erodin has a slower onset but a longer duration of action, while Imovane has a quicker onset but a shorter duration.
One advantage of Imovane is that it is less likely to cause drowsiness the next day.
When a physician adjusts your sleep medication based on your sleep patterns, it is important to follow their instructions and communicate your sleep situation thoroughly.
Do not adjust the dosage or discontinue the medication without consulting your doctor.
2.
There is limited academic literature regarding the dietary supplement Happy Banana Tablets, making it difficult to determine any potential interactions when used in conjunction with other medications.
However, Sepirone can be used at a maximum daily dosage of up to 60 mg, and there are few reports of overdose toxicity.
Symptoms of overdose may include drowsiness, dizziness, agitation, and nausea.
If you experience any of these symptoms, please return for a consultation with your physician for proper diagnosis.

Wishing you safety.

Reply Date: 2020/06/27

More Info


Managing sleep disorders can be a complex process, especially when it involves the use of medications and supplements. It’s essential to approach this with caution and under the guidance of a healthcare professional. In your case, you are currently prescribed Eurodin (Ulodin) and Imovane (Zopiclone), along with Sepirone (Buspirone), and you have also been given a supplement called Happy Banana tablets, which contain tryptophan.


Understanding Your Medications
1. Eurodin (Ulodin): This medication is typically used to treat insomnia. It works by affecting the chemicals in the brain that may be unbalanced in people with sleep problems. It is crucial to follow the prescribed dosage and timing to avoid potential side effects.

2. Imovane (Zopiclone): Similar to Eurodin, Zopiclone is a sedative-hypnotic that helps with sleep initiation and maintenance. It is generally considered safe for short-term use, but caution is advised when combining it with other sedatives or medications that affect the central nervous system.

3. Sepirone (Buspirone): This medication is primarily used to treat anxiety disorders. It works by affecting neurotransmitters in the brain, particularly serotonin. While it can help with anxiety, it is essential to monitor its interaction with other medications, especially those affecting serotonin levels.


Potential Risks of Combining Medications
Combining Eurodin and Imovane should be done cautiously, as both are sedatives. While your doctor has suggested that you can interchange them, it is crucial to ensure that the total dosage does not exceed the recommended limits. Overlapping sedative medications can lead to increased sedation, dizziness, and impaired cognitive function.


Serotonin Syndrome Risk
Regarding the use of Happy Banana tablets, which contain tryptophan, you are correct to be cautious. Tryptophan is a precursor to serotonin, and excessive serotonin levels can lead to serotonin syndrome, a potentially life-threatening condition. Symptoms of serotonin syndrome include confusion, rapid heart rate, high blood pressure, dilated pupils, muscle rigidity, and in severe cases, seizures or loss of consciousness.

Since you are already taking Sepirone, which increases serotonin levels, adding a tryptophan supplement could indeed raise your serotonin levels too high. It is essential to discuss this with your healthcare provider before adding any new supplements to your regimen.


Recommendations
1. Consult Your Doctor: Before making any changes to your medication or adding supplements, consult your prescribing physician. They can provide personalized advice based on your health history and current medications.

2. Monitor Symptoms: Keep a journal of your sleep patterns, any side effects you experience, and how you feel throughout the day. This information can be invaluable for your healthcare provider in adjusting your treatment plan.

3. Consider Non-Pharmacological Approaches: In addition to medication, consider incorporating behavioral therapies, cognitive-behavioral therapy for insomnia (CBT-I), and good sleep hygiene practices. This includes maintaining a regular sleep schedule, creating a restful environment, and avoiding stimulants like caffeine close to bedtime.

4. Educate Yourself: Understanding your medications and their potential interactions is crucial. Always read the information provided with your prescriptions and ask your pharmacist or doctor any questions you may have.

In conclusion, managing sleep disorders often requires a multifaceted approach, including careful medication management and lifestyle changes. Always prioritize communication with your healthcare providers to ensure safe and effective treatment.

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