Impact of Menstrual Delay Medication on Early Pregnancy: What to Know - Obstetrics and Gynecology

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What are the effects of abortifacients on a potentially early embryo?


Last month, my period started on June 15 and ended on June 18, which is usually normal for me as it lasts for 7 days.
I’m not sure why it suddenly stopped.
My husband and I are planning to have a baby, so we stopped using contraception starting June 24 and had intercourse.
I expect my next period to come on July 11, but I had to go on a business trip from July 9 to 10, so I visited a gynecologist to get medication to delay my period.
Since it has only been a week, I cannot determine if I am pregnant.
If I am pregnant, will taking the medication affect the embryo or the uterus? When I asked the doctor, they only replied that if I’m worried, I shouldn’t take it.
Could this cause instability in embryo implantation and lead to a miscarriage? Is there anything harmful to the fetus? Why didn’t the doctor directly inform us? Could taking the medication cause any effects? The prescription states that it is progesterone.

Xiao Xin, 20~29 year old female. Ask Date: 2020/07/05

Dr. Lin Manying reply Obstetrics and Gynecology


Hello Miss Hsiao-Hsin: If Medrone, a synthetic progesterone, is taken at a dosage of one pill per day for 3-5 days, the likelihood of embryo abnormalities is very low (statistically similar to the general population).
Natural progesterone has no impact.
The Hualien Hospital of the Ministry of Health and Welfare cares about your health.

Reply Date: 2020/07/05

More Info


When considering the impact of menstrual delay medication, particularly those containing hormones like progesterone, on early pregnancy, it is essential to understand both the physiological role of these medications and the potential risks involved.

Menstrual delay medications, often prescribed to manage irregular cycles or to postpone menstruation for various reasons, typically contain synthetic hormones such as progestins. These hormones work by mimicking the natural hormones in the body that regulate the menstrual cycle. In the context of early pregnancy, the presence of progesterone is crucial as it helps maintain the uterine lining, making it suitable for implantation of a fertilized egg.

If you have taken a menstrual delay medication shortly before or after conception, it is natural to be concerned about its effects on a potential pregnancy. Generally, if the medication was taken for a short period and you were not aware of an existing pregnancy, the risk of adverse effects is relatively low. Most studies indicate that the use of progestins in early pregnancy does not significantly increase the risk of miscarriage or congenital abnormalities, especially if the medication is used for a limited time.

However, the concern arises when considering the timing of medication use relative to conception. If the medication was taken after conception but before implantation, it could theoretically affect the implantation process. Some women worry that hormonal medications might disrupt the natural hormonal balance necessary for a successful pregnancy. While there is limited evidence to suggest that short-term use of progestins would lead to implantation failure or miscarriage, it is always best to consult with a healthcare provider for personalized advice.

In your case, since you mentioned that you were trying to conceive and had unprotected intercourse, it is crucial to monitor for signs of pregnancy. If you suspect you might be pregnant, taking a home pregnancy test after a missed period can provide clarity. If the test is positive, it is advisable to contact your healthcare provider to discuss your medication history and any concerns you may have.

Regarding the potential for the medication to cause instability in the embryo or lead to miscarriage, it is important to note that while any medication can carry risks, the specific risks associated with progestin use in early pregnancy are generally considered low. The body naturally produces progesterone during early pregnancy, and supplementing with synthetic forms can sometimes be beneficial, especially in cases of luteal phase defects or recurrent pregnancy loss.

If you are feeling anxious about the medication's effects, it is essential to have an open dialogue with your healthcare provider. They can provide reassurance, monitor your pregnancy, and suggest any necessary precautions or alternative treatments if needed. It is also worth noting that healthcare providers may sometimes be cautious in their responses to avoid causing undue alarm, which can lead to misunderstandings.

In summary, while there may be concerns about the impact of menstrual delay medications on early pregnancy, the evidence suggests that short-term use of progestins is unlikely to cause significant harm. However, every individual's situation is unique, and it is always best to seek personalized medical advice to address your specific circumstances and alleviate any concerns you may have about your health and the health of your potential pregnancy.

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