Combining Topical A Acid and Azelaic Acid: Best Practices and Tips - Dermatology

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The order of application for topical retinoic acid (tretinoin) and azelaic acid is typically to apply the retinoic acid first, followed by the azelaic acid?


1.
I currently use Aclovate cream before bed.
I would like to ask the doctor if I can combine the benefits of azelaic acid and topical retinoids by using Smet cream and Aclovate cream together? (Using Smet cream during the day and combining Smet cream with Aclovate cream before bed.)
2.
Will the effects of the two medications counteract or affect each other?
3.
If my skin can tolerate it and it's safe to combine, what would be the steps for using both creams together at night?
4.
Generally, how long does it take for topical medications to be absorbed through the skin?
5.
During the process of using topical retinoids, if there is itching that leads to skin breakdown, can I continue to apply the cream to that area? Thank you, doctor, for taking the time to respond.

Awei, 20~29 year old female. Ask Date: 2020/07/14

Dr. Wu Yuxin reply Dermatology


1.
Co-administration is not recommended.

2.
It may increase irritability.

3.
Not recommended.

4.
From a few minutes to several hours.

5.
It is advised to discontinue use.

Reply Date: 2020/07/14

More Info


When considering the combination of topical A acid (retinoic acid) and azelaic acid, it is essential to understand the properties and potential interactions of these two compounds. Both A acid and azelaic acid are effective in treating various skin conditions, including acne and hyperpigmentation, but they work through different mechanisms.

1. Combination Use: While it may be tempting to combine these two treatments to maximize benefits, it is generally not recommended to use them together in the same application. The reason for this is that both acids can be irritating to the skin, especially when used simultaneously. Using them on alternate days or at different times of the day (for example, azelaic acid in the morning and A acid at night) can help mitigate irritation while still allowing you to benefit from both treatments.

2. Effectiveness and Interaction: There is limited evidence to suggest that using A acid and azelaic acid together would significantly diminish their effectiveness. However, the risk of increased irritation is a concern. Both compounds can cause dryness, redness, and peeling, particularly when first introduced into a skincare regimen. Therefore, it is crucial to monitor your skin's response and adjust usage accordingly.

3. Application Steps: If you decide to use both products, a recommended routine could be:
- Morning: Cleanse your face, apply azelaic acid, and follow up with a moisturizer and sunscreen.

- Evening: Cleanse your face, apply A acid, and then follow with a gentle moisturizer to help combat dryness.

If you experience irritation, consider using one product every other day or reducing the frequency of application until your skin adjusts.

4. Absorption Time: Generally, topical medications can take anywhere from a few minutes to a couple of hours to be absorbed into the skin. However, it is advisable to wait at least 20-30 minutes after applying one product before applying another to allow for adequate absorption and to minimize potential irritation.

5. Dealing with Irritation: If you experience itching or irritation that leads to broken skin while using A acid, it is advisable to stop using the product on that area until it heals. Applying topical treatments over broken skin can lead to further irritation and may increase the risk of infection. Once the skin has healed, you can gradually reintroduce the A acid, starting with a lower frequency to assess tolerance.

In conclusion, while both A acid and azelaic acid can be beneficial for skin health, careful consideration of their use together is essential to avoid irritation. Always consult with a dermatologist or healthcare provider for personalized advice tailored to your skin type and condition. They can provide guidance on the best practices for incorporating these treatments into your skincare routine while minimizing side effects.

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