Can Glaucoma Patients Safely Use Minoxidil for Hair Loss? - Pharmacology

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Can glaucoma patients use Minoxidil long-term?


I have recently been diagnosed with glaucoma, but I also have hair issues, so I have been using products containing Minoxidil for a long time, such as Rogaine.
I did consult an ophthalmologist, but they advised me to ask a pharmacist.
I would like to inquire about the following: 1.
Is Minoxidil a type of steroid? 2.
Since Minoxidil has blood pressure-lowering effects, could it potentially lead to a faster progression of glaucoma? Thank you very much for your assistance.

Alan, 30~39 year old female. Ask Date: 2020/07/22

Dr. Liao Lingmei reply Pharmacology


Hello:
1.
Minoxidil is not a steroid; it was originally developed as an antihypertensive medication, but it was later discovered to have hair growth effects.
It is now commonly used in topical formulations, possibly due to its vasodilatory properties that enhance subcutaneous blood circulation, allowing hair follicle cells to transition from the telogen phase to the anagen phase.
2.
Minoxidil belongs to a class of antihypertensive medications that dilate arterial blood vessels and reduce peripheral vascular resistance.
It should not be used in patients with pheochromocytoma.
The pharmacological action of Minoxidil theoretically does not accelerate the progression of glaucoma.
However, there is limited research indicating that Minoxidil may cause eyelash growth in glaucoma animal models (rabbits).

Wishing you health and happiness!

Reply Date: 2020/07/22

More Info


Minoxidil is a well-known topical treatment for hair loss, particularly effective in cases of androgenetic alopecia, commonly referred to as male or female pattern baldness. However, your question about its safety for glaucoma patients is quite pertinent, especially considering the potential systemic effects of the medication.

1. Is Minoxidil a type of steroid?
No, Minoxidil is not a steroid. It is classified as a vasodilator, which means it works by relaxing blood vessels to improve blood flow. Originally developed as an oral medication for hypertension, it was later found to have the side effect of promoting hair growth, leading to its formulation as a topical solution for hair loss. Unlike steroids, which can have a range of systemic effects and side effects, Minoxidil primarily acts locally when applied to the scalp.

2. Does Minoxidil's blood pressure-lowering effect affect glaucoma progression?
Minoxidil does lower blood pressure, but its effect on glaucoma is not straightforward. Glaucoma is a condition characterized by increased intraocular pressure (IOP), which can lead to optic nerve damage and vision loss. The concern with using Minoxidil in glaucoma patients primarily revolves around its potential systemic absorption and effects. While topical Minoxidil is generally considered safe for most individuals, including those with glaucoma, it is crucial to monitor for any changes in IOP.

The relationship between blood pressure and glaucoma is complex. Some studies suggest that lower blood pressure may be beneficial for glaucoma patients, as it could reduce the pressure on the optic nerve. However, other studies indicate that very low blood pressure might also lead to reduced blood flow to the optic nerve, potentially exacerbating the condition. Therefore, while Minoxidil's blood pressure-lowering effects are not directly linked to worsening glaucoma, individual responses can vary.

For glaucoma patients considering Minoxidil, it is essential to consult with both an ophthalmologist and a healthcare provider familiar with hair loss treatments. They can provide personalized advice based on your specific health status, the severity of your glaucoma, and any other medications you may be taking.

In summary, while Minoxidil is not a steroid and does have blood pressure-lowering effects, its use in glaucoma patients can be safe under proper medical supervision. It is crucial to monitor your condition closely and report any changes in vision or eye pressure to your healthcare providers. Always prioritize open communication with your medical team to ensure the best outcomes for both your hair loss treatment and your eye health.

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