Risks of Taking Medication During Pregnancy: Thyroid and Insulin Concerns - Obstetrics and Gynecology

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I recently found out that I am pregnant, but I have not yet confirmed how far along I am.
I have hypothyroidism and polycystic ovary syndrome (PCOS).
The doctor mentioned that my cholesterol is also high, so they prescribed me three medications: Metformin 20 mg, Glimepiride, and Onglyza.
However, I stopped taking the medications around the end of July.
The doctor is now telling me that switching to insulin is necessary because Metformin could harm the fetus and lead to congenital anomalies.
What is the likelihood of fetal harm? Is it necessary to switch to insulin instead of continuing with the medications?

Sylvia Chen, 20~29 year old female. Ask Date: 2020/08/04

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, please follow your doctor's instructions for treatment.
Wishing you good health.

Reply Date: 2020/08/04

More Info


When considering the risks of taking medication during pregnancy, particularly in the context of thyroid issues and insulin management, it is crucial to understand the potential effects on both the mother and the developing fetus. Your situation involves hypothyroidism, polycystic ovary syndrome (PCOS), and elevated cholesterol levels, which complicate your medication management during pregnancy.

Firstly, it is important to recognize that certain medications can have varying degrees of risk during pregnancy. The classification of medications into categories (A, B, C, D, X) by the FDA helps in understanding their safety profiles. For instance, medications classified as Category D have evidence of risk to the fetus, while those in Category C may pose risks but are sometimes necessary if the benefits outweigh the risks.

In your case, the medications you mentioned, including the ones prescribed for managing cholesterol and thyroid function, need careful evaluation. For example, medications like metformin (often used for PCOS) and certain thyroid medications (like levothyroxine) are generally considered safer during pregnancy. However, some medications may pose risks, and it is essential to discuss these with your healthcare provider.

Regarding insulin, if your doctor has recommended switching to insulin therapy, it is likely because managing blood sugar levels is critical for both your health and the health of your baby. Uncontrolled blood sugar levels during pregnancy can lead to complications such as gestational diabetes, which can affect fetal development and lead to larger birth weights, increasing the risk of delivery complications.

The concern about "monster babies" or congenital anomalies is valid but often exaggerated. While some medications can increase the risk of certain birth defects, the risk varies significantly depending on the specific medication, the timing of exposure during pregnancy, and the dosage. For instance, certain oral hypoglycemics have been associated with risks, but insulin is generally considered safe and is often the preferred method for managing diabetes during pregnancy.

It is also essential to consider that stopping necessary medications abruptly can lead to worsening of your underlying conditions, which can also pose risks to both you and your baby. Therefore, it is crucial to have an open dialogue with your healthcare team, including your obstetrician and any specialists involved in your care. They can help you weigh the risks and benefits of continuing or switching medications and monitor your health closely throughout your pregnancy.

In summary, while there are risks associated with taking medications during pregnancy, the decision to continue or change your medication regimen should be made collaboratively with your healthcare provider. They will consider your specific health needs, the potential risks to your baby, and the overall management of your conditions. Regular monitoring and adjustments to your treatment plan can help ensure the best possible outcomes for both you and your baby. Always prioritize communication with your healthcare team to navigate these complex decisions effectively.

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