Fluctuations in Creatinine Levels: A Guide for Athletes - Family Medicine

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Creatinine issues


Hello, doctor.
During my freshman year (now preparing to enter my senior year), I had an entrance health examination, and my test results showed CR: 1 and BUN: 16, indicating normal kidney function.
I have not had any chronic illnesses since childhood.
I have been doing strength training every day, focusing on hypertrophy, and my diet has been high in protein.
During my freshman and sophomore years, I consumed protein equivalent to 1.5 to 2 times my body weight daily.
In my junior year, aiming to compete and reduce body fat, I increased my protein intake to about 2.5 times my body weight.
However, last week, I noticed persistent foamy urine, so I went to a nearby lab for blood and urine tests.
The results showed CR: 1.99, BUN: 26.8, and eGFR: 50.76, which shocked me.
I researched many international medical literature and sports studies indicating that a high-protein diet does not harm "healthy" kidneys but can burden and accelerate the deterioration of "existing" kidney diseases.
However, my freshman health examination was normal, with no chronic diseases like hypertension or diabetes, and I have not taken painkillers long-term.
Why is my CR so high? I am very worried about needing dialysis.
The data I received on August 17 (Monday) was after I had lifted my motorcycle on August 14 (Friday) before my workout, which might have strained my lower back, and I trained my back that day.
I am concerned, so on August 20 (Thursday), I visited a large hospital's nephrology department.
The doctor ordered tests for Creatinine (U), Creatinine (B), Total Protein, Albumin, CPK, S-GPT, Blood Sugar, BUN, and a urinalysis.
Here are the results: Total Protein: <4, Albumin: 4.53, CPK: 149, S-GPT: 16, CR (U): 43.16, CR (B): 1.17, Blood Sugar: 90, BUN: 16.
The urinalysis results were normal, with no hematuria or proteinuria.

Could you please explain why my initial CR was 1.99 and then dropped to a normal 1.17 three days later (during which I did not exercise and kept my protein intake below 1 times my body weight)? I am less concerned about the BUN value due to my long-term high-protein diet, but the fluctuating kidney function and CR really alarmed me.
Now that it has returned to normal, I am puzzled about the cause and whether I can continue with a high-protein diet.

Jack, 20~29 year old female. Ask Date: 2020/08/24

Dr. Wu Zongying reply Family Medicine


Hello: A long-term high-protein diet may increase the burden on the kidneys, so it is advisable to pay attention to your diet.
Your last creatinine level from the nephrology department at the major hospital was still normal; however, your previous creatinine test at the clinic was abnormal.
Personally, I do not recommend consuming so much protein for body composition purposes.
If you still have concerns about your kidney function, you can check if your eGFR (which should be indicated on the lab report) is below 90.
Additionally, you may consider testing for urine microalbumin, which can provide a more detailed assessment of urinary protein.

Reply Date: 2020/08/24

More Info


Understanding fluctuations in creatinine levels is crucial for athletes, especially those engaged in rigorous training and high-protein diets. Your experience highlights several important aspects of kidney function and how it can be influenced by diet, exercise, and even acute physical stress.

Creatinine is a waste product generated from muscle metabolism, and its levels in the blood are commonly used as an indicator of kidney function. Normal creatinine levels typically range from 0.6 to 1.2 mg/dL, but this can vary based on factors such as muscle mass, age, sex, and diet. In your case, the initial reading of 1.99 mg/dL was concerning, especially in the context of your high-protein diet and the physical stress from your workouts.

The increase in creatinine levels can be attributed to several factors:
1. High-Protein Diet: Consuming a diet high in protein can lead to elevated levels of urea and creatinine, as the body metabolizes protein. While research suggests that high-protein diets do not harm healthy kidneys, they can temporarily elevate creatinine levels, especially if the kidneys are under any stress.

2. Acute Physical Stress: You mentioned experiencing back pain after lifting your motorcycle and engaging in intense back workouts. Physical stress can lead to muscle breakdown (rhabdomyolysis), which can cause a temporary spike in creatinine levels due to the release of myoglobin and other muscle metabolites into the bloodstream.

3. Dehydration: Intense workouts can lead to dehydration, which can concentrate creatinine in the blood. If you were not adequately hydrated before your tests, this could have contributed to the elevated levels.

4. Temporary Kidney Function Changes: It's also possible that your kidneys were temporarily stressed due to the combination of high protein intake, physical exertion, and potential dehydration, leading to a transient increase in creatinine levels.

The subsequent drop in your creatinine levels to 1.17 mg/dL after three days of reduced protein intake and no exercise suggests that your kidneys are functioning well and can recover from acute stress. This is a positive sign and indicates that your kidneys are likely healthy.

Regarding your high-protein diet, it is essential to approach it with caution. While many athletes consume high-protein diets to support muscle growth and recovery, it is crucial to ensure that your kidneys can handle the increased workload. Here are some recommendations:
1. Monitor Your Intake: Consider moderating your protein intake to a level that is sufficient for your training needs without being excessive. A common recommendation for athletes is to consume around 1.2 to 2.0 grams of protein per kilogram of body weight, depending on the intensity of training.

2. Stay Hydrated: Ensure you are drinking enough water, especially when consuming a high-protein diet. Proper hydration helps the kidneys filter waste products more effectively.

3. Regular Check-Ups: Continue to monitor your kidney function through regular blood and urine tests, especially if you maintain a high-protein diet. This will help you catch any potential issues early.

4. Consult a Nutritionist: If you have concerns about your diet and its impact on your health, consider consulting a sports nutritionist. They can help tailor a diet plan that supports your training while considering your kidney health.

In summary, while your initial creatinine level was concerning, the subsequent normalization suggests that your kidneys are functioning well. However, it is essential to maintain a balanced approach to your diet and training to ensure long-term health.

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