Long-Term Use of Diane: Risks and Recommendations for PCOS Treatment

Long-term use of Diane (Diane-35) issues?

Hello, doctor.
I was diagnosed with polycystic ovary syndrome (PCOS) over two years ago.
At that time, the doctor prescribed Diane (Diane-35) for me to take continuously for six months.
After stopping the medication for about a year, I started taking Diane again in February of this year, and I have just finished my seventh pack.
I would like to ask: 1.
Are there any long-term side effects from taking Diane continuously for such a long time? 2.
Should I stop the medication now, or can I continue taking it? 3.
Generally, how long is it recommended to take Diane continuously before taking a break? Thank you!

Niming, 20~29 year old female. Ask Date: 2020/08/28

Dr. Cao Guotao reply Obstetrics and Gynecology

Hello, generally there are no long-term side effects.
Typically, one can take the medication for a year and then rest for a month.
Wishing you good health!

Reply Date: 2020/08/28

More Info

When considering the long-term use of Diane (Diane-35), particularly for managing conditions like Polycystic Ovary Syndrome (PCOS), it is essential to weigh the benefits against potential risks. Diane-35 is a combination oral contraceptive that contains cyproterone acetate and ethinyl estradiol. It is often prescribed for its anti-androgenic properties, which can help manage symptoms such as acne and hirsutism associated with PCOS.

1. Potential Long-Term Effects: Prolonged use of Diane-35 can lead to several side effects. While many women tolerate it well, some may experience adverse effects such as weight gain, mood changes, and an increased risk of thromboembolic events (blood clots). Additionally, long-term use may lead to the development of melasma (dark patches on the skin), especially in women with a history of sun exposure. Regular monitoring by a healthcare provider is crucial to assess any emerging side effects and to ensure that the benefits continue to outweigh the risks.

2. Continuation or Discontinuation of Medication: The decision to continue or stop Diane-35 should be made in consultation with your healthcare provider. If you are experiencing significant benefits without adverse effects, your doctor may recommend continuing the medication. However, if you have concerns about side effects or if you are considering pregnancy, it may be advisable to pause or switch medications. It is also important to consider your overall health, including any risk factors for cardiovascular disease, which can influence the safety of continued use.

3. Recommended Duration of Use: Generally, it is recommended that women take combination oral contraceptives like Diane-35 for no longer than 3-5 years continuously without a break, depending on individual health circumstances. After this period, a break of at least one month is often suggested to allow the body to reset and to monitor for any potential side effects. However, this can vary based on individual health profiles and the presence of any underlying conditions.

In summary, while Diane-35 can be an effective treatment for managing PCOS symptoms, it is essential to have regular follow-ups with your healthcare provider to monitor for side effects and to evaluate the need for continued therapy. If you have any concerns about your current treatment plan or if you are experiencing side effects, do not hesitate to reach out to your healthcare provider for personalized advice and potential alternatives.

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