Impact of Lupus on Sperm Motility: What to Expect After Five Years - Urology

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Sperm motility in patients with systemic lupus erythematosus?


A male patient diagnosed with lupus erythematosus five years ago has achieved medication control and is currently stable.
The doctor previously informed him that this condition could affect sperm motility.
Given that it has been five years since the diagnosis, will the sperm motility still be poor despite effective control, or can it return to normal? Will the sperm count also be normal, or will the motility be average with a shorter lifespan in the female reproductive tract?

Niming D, 30~39 year old female. Ask Date: 2020/09/24

Dr. Fu Shizhang reply Urology


It is recommended to visit the urology clinic for a semen analysis.

Reply Date: 2020/09/24

More Info


Lupus, or systemic lupus erythematosus (SLE), is an autoimmune disease that can affect various organs and systems in the body, including the reproductive system. In men, lupus has been associated with potential impacts on fertility, particularly concerning sperm motility and overall sperm quality. Given that you have been managing your lupus effectively for the past five years, it is important to understand how this condition and its treatment may influence your sperm health.

Firstly, the impact of lupus on sperm motility and count can vary significantly among individuals. While it is true that some studies suggest that men with lupus may experience reduced sperm motility and lower sperm counts, these effects can be influenced by several factors, including the severity of the disease, the presence of other health conditions, and the medications used for treatment. Since you mentioned that your condition is currently stable and well-controlled with medication, this is a positive sign.
Research indicates that the inflammatory processes associated with lupus can lead to oxidative stress, which may negatively affect sperm quality. However, if your lupus is under control, the inflammatory markers may be reduced, potentially allowing for improvements in sperm motility and count. It is also worth noting that the medications used to manage lupus can have varying effects on fertility. For instance, some immunosuppressive drugs may have a negative impact on sperm production, while others may not.

Regarding your specific question about sperm motility and count five years after diagnosis, it is possible that with effective management of your lupus, your sperm motility and count could return to normal or near-normal levels. However, this is not guaranteed, and individual results may vary. The best way to assess your current sperm health is through a semen analysis, which can provide detailed information about sperm count, motility, morphology, and overall quality.

As for the lifespan of sperm in the female reproductive tract, it is generally accepted that sperm can survive for up to five days after ejaculation, depending on the conditions within the female reproductive system. Factors such as cervical mucus quality and the timing of ovulation can influence sperm viability. Therefore, even if sperm motility is somewhat reduced, they may still be capable of fertilizing an egg if they are healthy enough and if the timing is right.

In conclusion, while lupus can impact sperm motility and count, effective management of the condition can lead to improvements in sperm health. It is advisable to consult with a urologist or a fertility specialist who can conduct a semen analysis and provide personalized recommendations based on your specific situation. They can also discuss any potential effects of your lupus medications on fertility and suggest strategies to optimize your reproductive health. Regular monitoring and open communication with your healthcare providers will be key in addressing any concerns you may have regarding fertility and family planning.

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